ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2004
The significance of the calcium signal in the outer hair cells and its possible role in tinnitus of cochlear origin.
Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Developmental Exposure to Polychlorinated Biphenyls Prevents Recovery from Noise-Induced Hearing Loss and Disrupts the Functional Organization of the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Developmental exposure to polychlorinated biphenyls prevents recovery from noise-induced hearing loss and disrupts the functional organization of the inferior colliculus.bioRxiv : the preprint server for biology · 2023Article
- Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions.Neural plasticity · 2021Review
- Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management.Neuropsychiatric disease and treatment · 2010Article
- A ratchet mechanism for amplification in low-frequency mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Hearing abilities at ultra-high frequency in patients with tinnitus.Clinical and experimental otorhinolaryngology · 2009Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Finely tuned changes in intracellular Ca(2+) concentration modulate a variety of cellular functions in eukaryotic cells. The cytosolic Ca(2+) concentration is also tightly controlled in the outer hair cells (OHCs), the highly specialized receptor and effector cells in the mammalian auditory epithelium, which are responsible for high sensitivity and sharp frequency discrimination in hearing. OHCs possess a complex system of transporters, pumps, exchangers, channels and binding proteins to develop and to halt the regulatory Ca(2+) signal. The crucial role of elevated intracellular Ca(2+) concentration in OHCs is to increase the efficacy of the electromechanical (electromotile) feedback via remodeling of the cortical cytoskeleton. Anomalies in the Ca(2+) signaling pathway may lead to hypersensitivity of the cochlear amplifier and subsequently trigger tinnitus of cochlear origin. This review describes the dynamics of Ca(2+) signaling in the OHCs and a model that may convey a putative mechanism of development of subjective idiopathic cochlear tinnitus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.