ArticleJournal of molecular histology2004
p75(NTR)-immunoreactivity in the subventricular zone of adult male rats: expression by cycling cells.
Article in Journal of molecular histology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Isolation of neural progenitor cells from the human adult subventricular zone based on expression of the cell surface marker CD271.Stem cells translational medicine · 2014Trial
- Differential contribution of TrkB and p75Frontiers in molecular neuroscience · 2023Article
- Drugs and Endogenous Factors as Protagonists in Neurogenic Stimulation.Stem cell reviews and reports · 2022Review
- Article
- Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles.Frontiers in neuroscience · 2016Review
- Signaling mechanisms regulating adult neural stem cells and neurogenesis.Biochimica et biophysica acta · 2013Review
- Glioma revisited: from neurogenesis and cancer stem cells to the epigenetic regulation of the niche.Journal of oncology · 2012Article
- Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair.Cell cycle (Georgetown, Tex.) · 2011Review
- The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis.BMC neuroscience · 2010Article
- Neurotrophic factor control of adult SVZ neurogenesis.Developmental neurobiology · 2010Review
- p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis.Experimental brain research · 2010Article
- Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches.BMB reports · 2009Review
- Brain injury expands the numbers of neural stem cells and progenitors in the SVZ by enhancing their responsiveness to EGF.ASN neuro · 2009Article
- Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor.PLoS biology · 2008Article
- Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus.Hippocampus · 2008Article
- The p75 neurotrophin receptor is a central regulator of glioma invasion.PLoS biology · 2007Article
- p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
While the study of in vitro regulation of neural stem cell lineage from both embryonic and adult neurospheres is greatly advanced, much less is known about factors acting in situ for neural stem cell lineage in adult brain. We reported that neurotrophin low affinity receptor p75(NTR) is present in the subventricular zone (SVZ) in adult male rats. We then characterized co-distribution of markers associated with precursor cells (nestin and PSA-NCAM) with growth factor receptors (p75(NTR), trkA, EGFr) and proliferation-associated antigens (Ki67 and BrDU-uptake) in adult male rat by immunocytochemistry and confocal laser scan microscopy. Distribution of p75(NTR)-immunoreactivity (IR) was investigated using different mono- and polyclonal antisera. p75(NTR-) is not co-distributed with glial fibrillary acid protein. It was found to be co-distributed with a small number of nestin-IR cells, whereas no coexistence with PSA-NCAM-IR was observed. Conversely, p75(NTR)-IR was present in numerous dividing cells (Ki-67-positive) and co-distributed with EGFr. In order to verify the possible association between p75(NTR) and cell death, we investigated co-distribution of p75(NTR)-IR with nuclear condensation images as visualized by Hoechst 33258 staining. While few images indicating nuclear condensation were observed in the SVZ, no coexistence with p75(NTR) was found. TrkA- and trkB-IR was not found in the SVZ. We also investigated p75(NTR) immunostaining on post-natal day 1 and day 16, because of the dramatic reduction of proliferating cells in SVZ over this time-interval. p75(NTR)-IR was not increased in the early post-natal phase. Thus, p75(NTR) seems to be associated with cell cycle regulation in SVZ in adult rat brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.