Trial reportPsychopharmacology2005
Reinforcing effects of methylphenidate: influence of dose and behavioral demands following drug administration.
Trial report in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Expectation to receive methylphenidate enhances subjective arousal but not cognitive performance.Experimental and clinical psychopharmacology · 2011Trial
- Modest abuse-related subjective effects of zolpidem in drug-naive volunteers.Behavioural pharmacology · 2011Trial
- Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD).Psychopharmacology · 2009Trial
- Acute physiological and behavioral effects of intranasal methamphetamine in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Trial
- A pharmacological analysis of stimulant-induced increases in smoking.Psychopharmacology · 2007Trial
- The reinforcing, subject-rated, performance, and cardiovascular effects of d-amphetamine: influence of sensation-seeking status.Addictive behaviors · 2007Trial
- Methylphenidate increases cigarette smoking.Psychopharmacology · 2005Trial
- Separate and Combined Effects of Naltrexone and Extended-Release Alprazolam on the Reinforcing, Subject-Rated, and Cardiovascular Effects of Methamphetamine.Journal of clinical psychopharmacology · 2016Article
- Influence of sensitization on the discriminative stimulus effects of methylphenidate in mice.Behavioural pharmacology · 2014Article
- Relationship between intranasal cocaine self-administration and subject-rated effects: predictors of cocaine taking on progressive-ratio schedules.Human psychopharmacology · 2014Article
- Relationship between oral D-amphetamine self-administration and ratings of subjective effects: do subjective-effects ratings correspond with a progressive-ratio measure of drug-taking behavior?Behavioural pharmacology · 2013Article
- Enhancement stimulants: perceived motivational and cognitive advantages.Frontiers in neuroscience · 2013Article
- A direct comparison of the behavioral and physiological effects of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in humans.Psychopharmacology · 2012Article
- High impulsivity in rats predicts amphetamine conditioned place preference.Pharmacology, biochemistry, and behavior · 2012Article
- Amphetamine self-administration in light and moderate drinkers.Alcoholism, clinical and experimental research · 2011Article
- The discriminative stimulus properties of methylphenidate in C57BL/6J mice.Behavioural pharmacology · 2011Article
- Oral methylphenidate establishes a conditioned place preference in rats.Neuroscience letters · 2011Article
- Human sex differences in d-amphetamine self-administration.Addiction (Abingdon, England) · 2010Article
- The reinforcing, self-reported performance and physiological effects of Delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in cannabis users.Behavioural pharmacology · 2010Article
- Amphetamine analogs methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) differentially affect speech.Psychopharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleThe reinforcing effects of stimulant drugs such as D-amphetamine, caffeine, and cocaine are modulated by behavioral demands following drug administration.
objectiveThe objective of this study was to assess the reinforcing effects of methylphenidate under different behavioral demands using a modified progressive-ratio procedure.
methodsThe reinforcing effects of oral methylphenidate (0, 10, 20, and 40 mg) were assessed in seven healthy adult volunteers under both performance and relaxation conditions. Performance sessions required volunteers to complete simple arithmetic problems for three 50-min blocks. Relaxation sessions required volunteers to sit quietly in a semi-reclined position in a darkened room for three 50-min blocks. Two sampling sessions (one performance and one relaxation session) always preceded two self-administration sessions (one performance and one relaxation session) and the order of relaxation and performance sessions was constant within a dose condition.
resultsMethylphenidate significantly increased break point and number of capsules earned on the modified progressive-ratio procedure as an increasing function of dose under the performance, but not the relaxation, condition. Methylphenidate produced comparable stimulant-like subject ratings under both the performance and relaxation conditions.
conclusionThe findings of the present experiment suggest that the reinforcing effects of methylphenidate, like D-amphetamine and cocaine, are influenced by behavioral demands following drug administration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.