ArticleOncogene2005
Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPAR(gamma) fusion oncogene.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Exploring molecular mechanisms of radioactive iodine therapy in thyroid cancer using single-cell RNA sequencing data.Discover oncology · 2026Article
- Thyroid and Breast Cancer in 2 Sisters With Monoallelic Mutations in the Ataxia Telangiectasia Mutated (Journal of the Endocrine Society · 2022Article
- Evaluation of Mutton Quality Characteristics of Dongxiang Tribute Sheep Based on Membership Function and Gas Chromatography and Ion Mobility Spectrometry.Frontiers in nutrition · 2022Article
- Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.Thyroid : official journal of the American Thyroid Association · 2019Article
- Identification and Validation of Core Genes Involved in the Development of Papillary Thyroid Carcinoma via Bioinformatics Analysis.International journal of genomics · 2019Article
- Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer.Cancer cell international · 2018Article
- Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples.Nature · 2015Article
- Pax-8-PPAR-γ fusion protein in thyroid carcinoma.Nature reviews. Endocrinology · 2014Review
- Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer.BMC cancer · 2014Article
- SIMPLE: A new regulator of endosomal trafficking and signaling in health and disease.Communicative & integrative biology · 2013Article
- Proteomic profiling of follicular and papillary thyroid tumors.European journal of endocrinology · 2012Article
- Diagnostic and prognostic markers in differentiated thyroid cancer.Current genomics · 2011Article
- The evolution of biomarkers in thyroid cancer-from mass screening to a personalized biosignature.Cancers · 2010Article
- Expression of the PAX8/PPARγ Fusion Protein Is Associated with Decreased Neovascularization In Vivo: Impact on Tumorigenesis and Disease Prognosis.Genes & cancer · 2010Article
- Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors.Journal of molecular endocrinology · 2010Review
- Translocations in epithelial cancers.Biochimica et biophysica acta · 2009Review
- PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- New agents in the treatment for malignancies of the salivary and thyroid glands.Hematology/oncology clinics of North America · 2008Review
- Molecular detection of PPAR gamma rearrangements and thyroid carcinoma in preoperative fine-needle aspiration biopsies.Endocrine pathology · 2008Article
- Role of surgeons in clinical trials for thyroid cancer.World journal of surgery · 2007Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The demonstration of the PAX8-PPAR(gamma) fusion oncogene in a subset of follicular thyroid tumors provides a new and promising starting point to dissect the molecular genetic events involved in the development of this tumor form. In the present study, we compared the gene expression profiles of follicular thyroid carcinomas (FTCs) bearing a PAX8-PPAR(gamma) fusion against FTCs that lack this fusion. Using unsupervised clustering and multidimensional scaling analyses, we show that FTCs possessing a PAX8-PPAR(gamma) fusion have a highly uniform and distinct gene expression signature that clearly distinguishes them from FTCs without the fusion. The PAX8-PPAR(gamma)(+) FTCs grouped in a defined cluster, where highly ranked genes were mostly associated with signal transduction, cell growth and translation control. Notably, a large number of ribosomal protein and translation-associated genes were concurrently underexpressed in the FTCs with the fusion. Taken together, our findings further support that follicular carcinomas with a PAX8-PPAR(gamma) rearrangement constitute a distinct biological entity. The current data represent one step to elucidate the molecular pathways in the development of FTCs with the specific PAX8-PPAR(gamma) fusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.