ArticleOncogene2005
Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit.Medical sciences (Basel, Switzerland) · 2018Review
- Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells.Cellular oncology (Dordrecht, Netherlands) · 2018Article
- Dual role of E-cadherin in the regulation of invasive collective migration of mammary carcinoma cells.Scientific reports · 2018Article
- TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis.PloS one · 2015Article
- Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-a-activated human hepatoma cells.Gene regulation and systems biology · 2014Article
- Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion.Cancer science · 2013Article
- Membrane type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at Lys581 increases cellular invasion through type I collagen.The Journal of biological chemistry · 2012Article
- Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.The Biochemical journal · 2012Review
- TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.PloS one · 2012Article
- Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.Carcinogenesis · 2011Article
- MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling.Molecular cancer research : MCR · 2011Article
- Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.The Journal of biological chemistry · 2011Article
- Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2.Cancer research · 2011Article
- Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes.The Journal of biological chemistry · 2010Article
- Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.Cancer research · 2010Article
- Tumour endoproteases: the cutting edge of cancer drug delivery?British journal of pharmacology · 2008Review
- Induction of Smad1 by MT1-MMP contributes to tumor growth.International journal of cancer · 2007Article
- Deciphering the molecular basis of breast cancer metastasis with mouse models.Reviews in endocrine & metabolic disorders · 2007Review
- Tetracycline regulated systems in functional oncogenomics.Translational oncogenomics · 2007Article
- Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase.Molecular cancer · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Overexpression of membrane-type-1 matrix metalloproteinase (MT1-MMP) in tumor cells has previously been shown to enhance tumor growth and metastasis. To establish if MT1-MMP is also able to confer tumorigenicity on nonmalignant epithelial cells, we transfected human MT1-MMP cDNA into Madin-Darby canine kidney (MDCK) cells expressing a tetracycline-repressible transactivator. Induction of MT1-MMP in the absence of doxycycline (Dox) was associated with activation of exogenous MMP-2 as well as with formation of large cysts and increased invasiveness in collagen matrices. Transfected cells were inoculated subcutaneously into two groups of nude mice, one of which received Dox to inhibit expression of MT1-MMP. Formation of tumor xenografts was observed in 11 of 17 mice maintained without Dox, but only in two of nine mice that received Dox (P<0.05). The xenografts were composed of tubular structures interspersed within a highly cellular stroma. The epithelial cells delimiting the lumen were polarized, as indicated by the basolateral distribution of Na,K-ATPase. Despite their differentiated appearance, the tumors lacked a well-defined boundary, and epithelial tubules invaded adjacent muscular layers. These results demonstrate that conditional expression of MT1-MMP in nonmalignant MDCK epithelial cells is by itself sufficient to drive formation of invasive tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.