ArticleImmunology2005
Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus.
Article in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Review
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- Altered transcriptional responses in the lungs of aged mice after influenza infection.Immunity & ageing : I & A · 2022Article
- Viral Respiratory Pathogens and Lung Injury.Clinical microbiology reviews · 2021Review
- Article
- Inflammatory risk factors for hypertriglyceridemia in patients with severe influenza.The Journal of international medical research · 2020Article
- Review
- Interleukin-18: Biological properties and role in disease pathogenesis.Immunological reviews · 2018Review
- New fronts emerge in the influenza cytokine storm.Seminars in immunopathology · 2017Review
- Innate immunity to influenza virus infection.Nature reviews. Immunology · 2014Review
- Caspase-1-induced pyroptotic cell death.Immunological reviews · 2011Review
- Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population.Hepatitis monthly · 2011Article
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.Nature immunology · 2010Article
- Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury.Journal of virology · 2010Article
- IL-1beta processing in host defense: beyond the inflammasomes.PLoS pathogens · 2010Review
- Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study.Critical care (London, England) · 2010Article
- Natural killer cells in infection and inflammation of the lung.Immunology · 2009Review
- Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance.The Journal of infectious diseases · 2008Article
- Article
- Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2006Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T helper 1 driven immune responses facilitate host defence during viral infections. Because interleukin-18 (IL-18) mediates T helper 1 driven immune responses, and since mature IL-18 is up-regulated in human macrophages after influenza virus infection in vitro, it has been suggested that IL-18 plays an important role in the immune response to influenza. To determine the role of IL-18 in respiratory tract infection with influenza, IL-18 gene-deficient (IL-18(-/-)) and normal wildtype mice were intranasally inoculated with influenza A virus. Influenza resulted in an increase in constitutively expressed IL-18 in the lungs of wildtype mice. The clearance of influenza A was inhibited by IL-18, as indicated by reduced viral loads on day 8 and day 12 after infection in IL-18(-/-) mice. This enhanced viral clearance correlated with increased CD4(+) T-cell activation in the lungs as reflected by CD69 expression on the cell surface. Surprisingly, interferon-gamma (IFN-gamma) levels were similar in the lungs of IL-18(-/-) mice and wildtype mice. Intracellular IFN-gamma staining revealed similar expression levels in lung-derived natural killer cells, CD4(+) and CD8(+) T cells, indicating that IFN-gamma production is IL-18-independent during influenza virus infection. Tumour necrosis factor-alpha production by CD4(+) T cells was significantly lower in IL-18(-/-) mice than in wildtype mice. Our data indicate that endogenous IL-18 impairs viral clearance during influenza A infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.