ArticleJournal of virology1992
Nuclear factor I is specifically targeted to discrete subnuclear sites in adenovirus type 2-infected cells.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Viral and cellular interactions during adenovirus DNA replication.FEBS letters · 2019Review
- DNA virus replication compartments.Journal of virology · 2014Review
- Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines.The Journal of biological chemistry · 2013Article
- Adeno-associated virus infection of murine fibroblasts with help provided by mouse adenovirus.Virology · 2009Article
- Identification of a new human adenovirus protein encoded by a novel late l-strand transcription unit.Journal of virology · 2007Article
- A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication.Advances in virus research · 2007Review
- Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes.Journal of virology · 2005Article
- The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication.Journal of virology · 2004Article
- Interaction of the DNA modifying proteins VirD1 and VirD2 of Agrobacterium tumefaciens: analysis by subcellular localization in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix.Journal of virology · 1998Article
- Role of preterminal protein processing in adenovirus replication.Journal of virology · 1997Article
- Subcellular compartmentalization of adeno-associated virus type 2 assembly.Journal of virology · 1997Article
- The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition.The Journal of cell biology · 1996Article
- Tyrosine kinase-dependent release of an adenovirus preterminal protein complex from the nuclear matrix.Journal of virology · 1996Article
- Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers.Journal of virology · 1996Article
- Regulation of the DNA-binding and transcriptional activities of Xenopus laevis NFI-X by a novel C-terminal domain.Molecular and cellular biology · 1995Article
- Dynamic organization of splicing factors in adenovirus-infected cells.Journal of virology · 1995Article
- Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells.The EMBO journal · 1994Article
- Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells.Journal of virology · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the S phase of the eukaryotic cell cycle and in virus-infected cells, DNA replication takes place at discrete sites in the nucleus, although it is not clear how the proteins involved in the replicative process are directed to these sites. Nuclear factor I is a cellular, sequence-specific DNA-binding protein utilized by adenovirus type 2 to facilitate the assembly of a nucleoprotein complex at the viral origin of DNA replication. Immunofluorescence experiments reveal that in uninfected cells, nuclear factor I is distributed evenly throughout the nucleus. However, after a cell is infected with adenovirus type 2, the distribution of nuclear factor I is dramatically altered, being colocalized with the viral DNA-binding protein in a limited number of subnuclear sites which bromodeoxyuridine pulse-labeling experiments have identified as sites of viral DNA replication. Experiments with adenovirus type 4, which does not require nuclear factor I for viral DNA replication, indicate that although the adenovirus type 4 DNA-binding protein is localized to discrete nuclear sites, this does not result in the redistribution of nuclear factor I. Localization of nuclear factor I to discrete subnuclear sites is therefore likely to represent a specific targeting event that reflects the requirement for nuclear factor I in adenovirus type 2 DNA replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.