ArticlePlant molecular biology2004
Plant class B HSFs inhibit transcription and exhibit affinity for TFIIB and TBP.
Article in Plant molecular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 116 citations in OpenAlex.
- Genome-Wide Analysis of Heat Shock Transcription Factors (HSFs) in Kelp (Plants (Basel, Switzerland) · 2026Article
- PtoHsfB1 regulates growth and salt response by affecting ABA biosynthesis inForestry research · 2026Article
- Genome-wide identification of heat shock factors in Myricaria laxiflora and their response to abiotic stresses.BMC genomics · 2025Article
- Cloning and expression analysis of RhHsf24 gene in Rose (Rosa hybrida).Scientific reports · 2025Article
- Overexpression of the general transcription factor OsTFIIB5 alters rice development and seed quality.Plant cell reports · 2025Article
- The general transcription factors (GTFs) of RNA polymerase II and their roles in plant development and stress responses.Critical reviews in biochemistry and molecular biology · 2024Review
- MaHsf24, a novel negative modulator, regulates cold tolerance in banana fruits by repressing the expression of HSPs and antioxidant enzyme genes.Plant biotechnology journal · 2024Article
- Involvement of CgHSFB1 in the regulation of self-incompatibility in 'Shatian' pummelo.Plant molecular biology · 2024Article
- The miR165/166-PHABULOSA module promotes thermotolerance by transcriptionally and posttranslationally regulating HSFA1.The Plant cell · 2023Article
- Ectopic overexpression of TaHsfA5 promotes thermomorphogenesis in Arabidopsis thaliana and thermotolerance in Oryza sativa.Plant molecular biology · 2023Article
- Genome-Wide Characterization and Expression of theInternational journal of molecular sciences · 2023Article
- The class B heat shock factor HSFB1 regulates heat tolerance in grapevine.Horticulture research · 2023Article
- The impact of heat stress in plant reproduction.Frontiers in plant science · 2023Review
- The heat stress transcription factor family in Aegilops tauschii: genome-wide identification and expression analysis under various abiotic stresses and light conditions.Molecular genetics and genomics : MGG · 2022Article
- A Heat Shock Transcription FactorInternational journal of molecular sciences · 2022Article
- A maize heat shock factor ZmHsf11 negatively regulates heat stress tolerance in transgenic plants.BMC plant biology · 2022Article
- The intersection between circadian and heat-responsive regulatory networks controls plant responses to increasing temperatures.Biochemical Society transactions · 2022Review
- Analyzing the regulatory role of heat shock transcription factors in plant heat stress tolerance: a brief appraisal.Molecular biology reports · 2022Review
- The Heat Stress Transcription Factor LlHsfA4 Enhanced Basic Thermotolerance through Regulating ROS Metabolism in Lilies (International journal of molecular sciences · 2022Article
- Phylogenetic and expression analyses of HSF gene families in wheat (Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant heat shock transcription factors (HSFs) are capable of transcriptional activation (class A HSFs) or both, activation and repression (class B HSFs). However, the details of mechanism still remain unclear. It is likely, that the regulation occurs through interactions of HSFs with general transcription factors (GTFs), as has been described for numerous other transcription factors. Here, we show that class A HSFs may activate transcription through direct contacts with TATA-binding protein (TBP). Class A HSFs can also interact weakly with TFIIB. Conversely, class B HSFs inhibit promoter activity through an active mechanism of repression that involves the C-terminal regulatory region (CTR) of class B HSFs. Deletion analysis revealed two sites in the CTR of soybean GmHSFB1 potentially involved in protein-protein interactions with GTFs: one is the repressor domain (RD) located in the N-terminal half of the CTR, and the other is a TFIIB binding domain (BD) that shows affinity for TFIIB and is located C-terminally from the RD. A Gal4 DNA binding domain-RD fusion repressed activity of LexA-activators, while Gal4-BD proteins synergistically activated strong and weak transcriptional activators. In vitro binding studies were consistent with this pattern of activity since the BD region alone interacted strongly with TFIIB, and the presence of RD had an inhibitory effect on TFIIB binding and transcriptional activation.
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