ArticleHeart (British Cardiac Society)2005
Acute coronary syndrome and chronic infection in the Cork coronary care case-control study.
Article in Heart (British Cardiac Society), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications.Annals of clinical microbiology and antimicrobials · 2025Pooled it
- Effect of Helicobacter pylori infection on the risk of acute coronary syndrome: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Cytomegalovirus infection and coronary heart disease risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Review
- The evaluation of the effect of Helicobacter pylori infection on choroidal thickness.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Association between Bacterial Infection and Peripheral Vascular Disease: A Review.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016Review
- Clinical significance of Helicobacter pylori infection in patients with acute coronary syndromes: an overview of current evidence.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Review
- Prognostic role of Helicobacter pylori infection in acute coronary syndrome: a prospective cohort study.Cardiovascular journal of Africa · 2012Article
- Hepatitis C virus infection and the risk of coronary disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Article
- Article
- Helicobacter pylori and coronary artery disease: which is the better target population?Digestive diseases and sciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between chronic infection and cumulative burden of infection and acute coronary syndrome.
designThe 5C (Cork coronary care case-control) study was a community based case-control study. Patients and controls underwent a standard physical examination and had blood samples taken for serological analysis for Helicobacter pylori (IgG), Chlamydia pneumoniae (IgA, IgM, and IgG), cytomegalovirus (IgG), and herpes simplex virus types 1 and 2 (IgG).
settingPatients were recruited from four hospitals in Cork City and Mallow Town. Controls, individually matched on age and sex, were selected by incident density sampling from the same general practices as the referent case.
main outcome measuresAge and sex adjusted and fully adjusted odds ratios for acute coronary syndrome by seropositivity and by increasing number of infections.
resultsCases and controls did not differ significantly in seropositivity to C pneumoniae, cytomegalovirus, herpes simplex viruses, and H pylori. In unconditional logistic regression analysis adjusted for age, sex, waist to hip ratio, smoking, physical activity, alcohol consumption, and social class there was no evidence of an increasing risk for acute coronary syndrome with increasing burden of infection.
conclusionsThe findings do not support an association between specific infectious agents and acute coronary syndrome and do not provide evidence of a burden of infection effect.
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Registered trials
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