ReviewBMJ (Clinical research ed.)2004
The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.
Review in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular diseases.The Cochrane database of systematic reviews · 2017Pooled it
- Fixed-dose combination therapy for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2014Pooled it
- Functional MedicineIntegrative medicine (Encinitas, Calif.) · 2022Article
- The tyranny of the averages and the indiscriminate use of risk factors in public health: The case of coronary heart disease.SSM - population health · 2017Article
- Article
- Fixed-dose combination therapy for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2012Article
- Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice.PloS one · 2012Article
- Cocoa and chocolate in human health and disease.Antioxidants & redox signaling · 2011Review
- Lifestyle modifications and the resolution of obstructive sleep apnea syndrome: a case report.Journal of chiropractic medicine · 2011Article
- Midlife healthy-diet index and late-life dementia and Alzheimer's disease.Dementia and geriatric cognitive disorders extra · 2011Article
- Dark chocolate: consumption for pleasure or therapy?Journal of thrombosis and thrombolysis · 2009Review
- The Building Healthy Lifestyles Conference: Modifying Lifestyles to Enhance Physical Activity, Diet, and Reduce Cardiovascular Disease.American journal of lifestyle medicine · 2009Article
- Current advances in research and clinical applications of PLGA-based nanotechnology.Expert review of molecular diagnostics · 2009Review
- Issues to consider in the pharmaceutical development of a cardiovascular polypill.Nature clinical practice. Cardiovascular medicine · 2009Review
- Chocolate, well-being and health among elderly men.European journal of clinical nutrition · 2008Article
- Population health: challenges for science and society.The Milbank quarterly · 2007Article
- Cardiovascular risk models.BMJ (Clinical research ed.) · 2007Article
- Chocolate and prevention of cardiovascular disease: a systematic review.Nutrition & metabolism · 2006Article
- Dietary approaches that delay age-related diseases.Clinical interventions in aging · 2006Review
- The origins of human disease: a short story on "where diseases come from".Journal of epidemiology and community health · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAlthough the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls. The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal.
methodsData on the ingredients of the Polymeal were taken from the literature. The evidence based recipe included wine, fish, dark chocolate, fruits, vegetables, garlic, and almonds. Data from the Framingham heart study and the Framingham offspring study were used to build life tables to model the benefits of the Polymeal in the general population from age 50, assuming multiplicative correlations.
resultsCombining the ingredients of the Polymeal would reduce cardiovascular disease events by 76%. For men, taking the Polymeal daily represented an increase in total life expectancy of 6.6 years, an increase in life expectancy free from cardiovascular disease of 9.0 years, and a decrease in life expectancy with cardiovascular disease of 2.4 years. The corresponding differences for women were 4.8, 8.1, and 3.3 years.
conclusionThe Polymeal promises to be an effective, non-pharmacological, safe, cheap, and tasty alternative to reduce cardiovascular morbidity and increase life expectancy in the general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.