Evidence map›Paper›PMID 15603749›Full record

ReviewMutation research2005

Stress responses and genetic variation in bacteria.

Patricia L Foster

Open access · greenAbstract readReview
In one paragraph

Review in Mutation research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 201 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Effect of encapsulation technology andFrontiers in microbiology · 2025
    Article
  5. Article
  6. Review
  7. Boosting the Antibacterial Activity of Azithromycin on Multidrug-ResistantInternational journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Transcriptomic Response Analysis ofFrontiers in microbiology · 2021
    Article
  16. Targeting evolution of antibiotic resistance by SOS response inhibition.Computational and structural biotechnology journal · 2021
    Review
  17. Article
  18. Expression of stress regulator and virulence genes ofFood science and biotechnology · 2020
    Article
  19. Evolutionary Rescue of an EnvironmentalFrontiers in microbiology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Patricia L FosterDepartment of Biology, Indiana University, Jordan Hall, 1001 East Third Street, Bloomington, IN 47405, USA. pfoster@indiana.edu
Indiana University Bloomington · US

Funding

Regulation of an Error-Prone PolymeraseR01GM065175 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI FOSTER, PATRICIA LORRAINE · 2002 to 2011
$2.0M
NIGMS NIH HHS GM065175NIGMS NIH HHS R01 GM065175
6 · The paper itself

Abstract

Under stressful conditions mechanisms that increase genetic variation can bestow a selective advantage. Bacteria have several stress responses that provide ways in which mutation rates can be increased. These include the SOS response, the general stress response, the heat-shock response, and the stringent response, all of which impact the regulation of error-prone polymerases. Adaptive mutation appears to be process by which cells can respond to selective pressure specifically by producing mutations. In Escherichia coli strain FC40 adaptive mutation involves the following inducible components: (i) a recombination pathway that generates mutations; (ii) a DNA polymerase that synthesizes error-containing DNA; and (iii) stress responses that regulate cellular processes. In addition, a subpopulation of cells enters into a state of hypermutation, giving rise to about 10% of the single mutants and virtually all of the mutants with multiple mutations. These bacterial responses have implications for the development of cancer and other genetic disorders in higher organisms.

Indexed as

MutationAdaptation, BiologicalBacteriaBacterial ProteinsDNA-Directed DNA PolymeraseGenes, BacterialLac OperonRecombination, GeneticSOS Response, GeneticsBacterial ProteinsDNA-Directed DNA Polymerase

Identifiers

PMID15603749
PMCPMC2729700
OpenAlexW1977111165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.