ReviewJournal of molecular medicine (Berlin, Germany)2004
The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine.
Review in Journal of molecular medicine (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
- Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2 h apart.Psychopharmacology · 2013Trial
- Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans.British journal of pharmacology · 2012Trial
- In vivo pharmacokinetic, pharmacodynamic and brain concentration comparison of fentanyl and para-fluorofentanyl in rats.Archives of toxicology · 2025Article
- Associations between short-term ambient temperature exposure and emergency department visits for amphetamine, cocaine, and opioid use in California from 2005 to 2019.Environment international · 2023Article
- Worsening of the Toxic Effects of (±)International journal of molecular sciences · 2021Article
- Designer drugs: mechanism of action and adverse effects.Archives of toxicology · 2020Review
- P2X7 Receptor in the Management of Energy Homeostasis: Implications for Obesity, Dyslipidemia, and Insulin Resistance.Frontiers in endocrinology · 2020Review
- Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts.International journal of molecular sciences · 2019Article
- Conserving wildlife in a changing world: Understanding capture myopathy-a malignant outcome of stress during capture and translocation.Conservation physiology · 2019Review
- Individuals with Hyperthyroidism are More Susceptible to having a Serious Serotonin Syndrome Following MDMA (Ecstasy) Administration in Rats.Annals of forensic research and analysis · 2018Article
- A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation.The Journal of physiology · 2016Article
- Drugs and bugs: turning on the heat through UCP1 and UCP3.The Journal of physiology · 2016Article
- Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Synthetic cathinones ("bath salts").The Journal of emergency medicine · 2014Review
- Catechol-o-methyltransferase and 3,4-({+/-})-methylenedioxymethamphetamine toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Prenatal antidepressant exposure: clinical and preclinical findings.Pharmacological reviews · 2014Review
- Protective effects of N-acetylcysteine on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague-Dawley rats.Metabolic brain disease · 2013Article
- Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.British journal of pharmacology · 2012Review
- Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.Toxicology letters · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body temperature regulation involves a homeostatic balance between heat production and dissipation. Sympathetic agents such as 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) can disrupt this balance and as a result produce an often life-threatening hyperthermia. The hyperthermia induced by MDMA appears to result from the activation of the sympathetic nervous system (SNS) and the hypothalamic-pituitary-thyroid/adrenal axis. Norepinephrine release mediated by MDMA creates a double-edged sword of heat generation through activation of uncoupling protein (UCP3) along with alpha1- and beta3-adrenoreceptors and loss of heat dissipation through SNS-mediated vasoconstriction. This review examines cellular mechanisms involved in MDMA-induced thermogenesis from UCP activation to vasoconstriction and how these mechanisms are related to other thermogenic conditions and potential treatment modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.