ArticlePediatric surgery international2005
Oral arginine improves intestinal recovery following ischemia-reperfusion injury in rat.
Article in Pediatric surgery international, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Phage-Display Immunoprecipitation Sequencing Reveals Distinct Antibody Signatures Against Bacterial Flagellins Associated With Treatment Response in Crohn's Disease.Clinical and translational gastroenterology · 2026Article
- Exploring the influence and mechanism of different frying methods on the flavor quality of low-salt sour meat.Food chemistry: X · 2024Article
- Article
- MicroRNA-1297 participates in the repair of intestinal barrier injury in patients with HIV/AIDS via negative regulation of PLCβ1.Molecular and cellular biochemistry · 2022Article
- Use of sildenafil and L-arginine in an experimental rat model for the prevention of neonatal necrotizing enterocolitis.Scientific reports · 2022Article
- Article
- Heat Stress-Mediated Activation of Immune-Inflammatory Pathways.Antibiotics (Basel, Switzerland) · 2021Review
- Present and Future Therapeutic Approaches to Barrier Dysfunction.Frontiers in nutrition · 2021Review
- Effects of dietary components on intestinal permeability in health and disease.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Effects of Zinc Oxide and Arginine on the Intestinal Microbiota and Immune Status of Weaned Pigs Subjected to High Ambient Temperature.Animals : an open access journal from MDPI · 2020Article
- A novel histidine-tryptophan-ketoglutarate formulation ameliorates intestinal injury in a cold storage and ex vivo warm oxygenated reperfusion model in rats.Bioscience reports · 2020Article
- Beyond Heat Stress: Intestinal Integrity Disruption and Mechanism-Based Intervention Strategies.Nutrients · 2020Review
- The Gastrointestinal Exertional Heat Stroke Paradigm: Pathophysiology, Assessment, Severity, Aetiology and Nutritional Countermeasures.Nutrients · 2020Review
- Arginine affects growth and integrity of grass carp enterocytes by regulating TOR signaling pathway and tight junction proteins.Fish physiology and biochemistry · 2019Article
- Physiological Effects of Dietary Amino Acids on Gut Health and Functions of Swine.Frontiers in veterinary science · 2019Review
- Aspartate attenuates intestinal injury and inhibits TLR4 and NODs/NF-κB and p38 signaling in weaned pigs after LPS challenge.European journal of nutrition · 2017Article
- Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following acetic acid induced intestinal injury in rats.Nutrition & metabolism · 2013Article
- Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat.BMC gastroenterology · 2012Article
- Enteral arginine does not increase superior mesenteric arterial blood flow but induces mucosal growth in neonatal pigs.The Journal of nutrition · 2011Article
- L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells.Amino acids · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arginine and nitric oxide are critical to the normal physiology of the gastrointestinal tract and maintain the mucosal integrity of the intestine in various intestinal disorders. In the present study, we evaluate the effects of oral arginine (ARG) supplementation on intestinal structural changes, enterocyte proliferation, and apoptosis following intestinal ischemia-reperfusion (IR) in the rat. Male Sprague-Dawley rats were divided into three experimental groups: sham rats underwent laparotomy and superior mesenteric artery mobilization, IR rats underwent superior mesenteric artery occlusion for 30 min following by 24 h of reperfusion, and IR-ARG rats were treated with enteral arginine given in drinking water (2%) 48 h before and following IR. Intestinal structural changes, enterocyte proliferation, and enterocyte apoptosis were determined 24 h following IR. A nonparametric Kruskal-Wallis ANOVA test was used for statistical analysis with p <0.05 considered statistically significant. IR rats demonstrated a significant decrease in bowel weight in duodenum and jejunum, mucosal weight in jejunum and ileum, and villus height in jejunum and ileum compared with control animals. IR rats also had a significantly lower cell proliferation index in jejunum and ileum and a higher apoptotic index in ileum compared with control rats. IR-ARG animals demonstrated greater duodenal and jejunal bowel weight; duodenal, jejunal, and ileal mucosal weight; and jejunal and ileal cell proliferation index compared with IR animals. In conclusion, oral ARG administration improves mucosal recovery following IR injury in the rat.
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