ArticleGenes and immunity2005
Divergent patterns of linkage disequilibrium and haplotype structure across global populations at the interleukin-13 (IL13) locus.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.Nature communications · 2026Pooled it
- African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.Nature communications · 2026Article
- Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility.Genome biology and evolution · 2017Article
- Development and evaluation of the first high-throughput SNP array for common carp (Cyprinus carpio).BMC genomics · 2014Article
- Genetic variations of cytokines and cytokine receptors in psoriasis patients from china.International journal of genomics · 2014Article
- Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure.Human genetics · 2013Article
- Crohn's disease and genetic hitchhiking at IBD5.Molecular biology and evolution · 2012Article
- Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population.PloS one · 2012Article
- Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.Pharmacogenomics · 2011Article
- Hunter-gatherer genomic diversity suggests a southern African origin for modern humans.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Interleukin-13 signaling and its role in asthma.The World Allergy Organization journal · 2011Article
- Phred-Phrap package to analyses tools: a pipeline to facilitate population genetics re-sequencing studies.Investigative genetics · 2011Article
- Article
- Methodological challenges of genome-wide association analysis in Africa.Nature reviews. Genetics · 2010Review
- Interleukin13 haplotypes and susceptibility of Iranian women to breast cancer.Molecular biology reports · 2009Article
- Genetic structure in African populations: implications for human demographic history.Cold Spring Harbor symposia on quantitative biology · 2009Review
- Statistical power analysis of neutrality tests under demographic expansions, contractions and bottlenecks with recombination.Genetics · 2008Article
- Recent advances in asthma genetics.Respiratory research · 2008Review
- IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.Respiratory research · 2008Article
- African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping.Annual review of genomics and human genetics · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-13 (IL-13) is a cytokine involved in Th2 immune response, which plays a role in susceptibility to infection by extracellular parasites as well as complex diseases of the immune system such as asthma and allergies. To determine the pattern of genetic diversity at the IL13 gene, we sequenced 3950 bp encompassing the IL13 gene and its promoter in 264 chromosomes from individuals originating from East and West Africa, Europe, China and South America. Thirty-one single-nucleotide polymorphisms (SNPs) arranged in 88 haplotypes were indentified, including the nonsynonymous substitution Arg130Gln in exon 4, which differs in frequency across ethnic groups. We show that genetic diversity and linkage disequilibrium (LD) are not evenly distributed across the gene and that sites in the 5' and 3' regions of the gene show strong differentiation among continental groups. We observe a divergent pattern of haplotype variation and LD across geographic regions and we identify a set of htSNPs that will be useful for functional genetic association studies of complex disease. We use several statistical tests to distinguish the effects of natural selection and demographic history on patterns of genetic diversity at the IL13 locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.