ArticleMolecular and cellular biology2005
NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 82 citations in OpenAlex.
- Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A.Open biology · 2022Review
- Transcription factor competition at the γ-globin promoters controls hemoglobin switching.Nature genetics · 2021Article
- On the NF-Y regulome as in ENCODE (2019).PLoS computational biology · 2020Article
- A R2R3-MYB gene-based marker for the non-darkening seed coat trait in pinto and cranberry beans (Phaseolus vulgaris L.) derived from 'Wit-rood boontje'.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis.Experimental & molecular medicine · 2019Article
- Involvement of the Transcriptional Coactivator ThMBF1 in the Biocontrol Activity ofFrontiers in microbiology · 2017Article
- NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription.Oncotarget · 2016Article
- A high definition look at the NF-Y regulome reveals genome-wide associations with selected transcription factors.Nucleic acids research · 2016Article
- Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells.Biochimica et biophysica acta · 2014Article
- Fundamentals of vitamin D hormone-regulated gene expression.The Journal of steroid biochemistry and molecular biology · 2014Review
- Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors.Molecular cell · 2014Article
- Article
- Hepatitis B Virus X Protein Up-Regulates AKR1C1 Expression Through Nuclear Factor-Y in Human Hepatocarcinoma Cells.Hepatitis monthly · 2013Article
- The promiscuous life of plant NUCLEAR FACTOR Y transcription factors.The Plant cell · 2012Review
- Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.Virology · 2012Article
- Article
- Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.PloS one · 2012Article
- The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancers.Journal of cellular biochemistry · 2011Article
- Specific inhibition of NF-Y subunits triggers different cell proliferation defects.Nucleic acids research · 2011Article
- NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons.Cell death and differentiation · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoclast differentiation factor (ODF)/receptor activator of NF-kappaB ligand is essential for inducing the differentiation of mature osteoclasts. We find that nuclear factor Y (NF-Y) binds to the CCAAT box on the ODF promoter and regulates its basal transcriptional activity. The CCAAT box on the ODF gene is required for its transcriptional induction by vitamin D3, suggesting that NF-Y coregulates this promoter along with VDR. Chromatin immunoprecipitation analysis reveals that NF-Y is required for the recruitment of RNA polymerase II (RNAPII) and TATA box binding protein on the ODF promoter. Stimulation with vitamin D3 facilitates the recruitment of VDR and p300 onto the ODF promoter, resulting in acetylation of histone H4 in an NF-Y-independent manner. ODF gene induction by parathyroid hormone or prostaglandin E is also dependent on NF-Y. Furthermore, NF-Y is essential for the recruitment of RNAPII onto other CCAAT box-containing promoters, such as those of osteopontin, CYP24, and E2F1. These results suggest that NF-Y recruits RNAPII and general transcription factors onto various CCAAT box-containing promoters in response to various inductions to permit strong transcriptional activation independently of histone modifications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.