ArticleMolecular and cellular biology2005
Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Review
- Altered endocytosis in cellular senescence.Ageing research reviews · 2021Review
- Biological Functions of the ING Proteins.Cancers · 2019Review
- ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth.Oncogene · 2014Article
- Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways.Molecular and cellular biochemistry · 2013Article
- The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.PLoS biology · 2013Article
- Adenovirus-mediated expression of p33(ING1b) induces apoptosis and inhibits proliferation in gastric adenocarcinoma cells in vitro.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2012Article
- Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins.The Journal of biological chemistry · 2012Article
- The ING tumor suppressors in cellular senescence and chromatin.Cell & bioscience · 2011Article
- ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma.Journal of oncology · 2011Article
- p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase.Molecular cancer research : MCR · 2010Article
- The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain.Molecular endocrinology (Baltimore, Md.) · 2009Article
- The ING gene family in the regulation of cell growth and tumorigenesis.Journal of cellular physiology · 2009Review
- Critical pathways in cellular senescence and immortalization revealed by gene expression profiling.Oncogene · 2008Review
- Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma.Journal of neuro-oncology · 2007Article
- Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.Cancer research · 2007Article
- Article
- What has senescence got to do with cancer?Cancer cell · 2005Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ING1 was identified as an inhibitor of growth and has been described as a tumor suppressor. Furthermore, the expression of ING1 is induced in senescent cells and antisense ING1 extends the proliferative life span of primary human fibroblasts. Cooperation of p33ING1 with p53 has been suggested to be an important function of ING1 in cell cycle control. Intriguingly, it has been shown that p33ING1 is associated with histone acetylation as well as with histone deacetylation function. Here we show that p33ING1 is a potent transcriptional silencer in various cell types. However, the silencing function is independent of the presence of p53. By use of deletion mutants two potent autonomous and transferable silencing domains were identified, but no evidence of an activation domain was found. The amino (N)-terminal silencing domain is sensitive to the histone deacetylase inhibitor trichostatin A (TSA) whereas the carboxy-terminal silencing function is resistant to TSA, suggesting that p33ING1 confers gene silencing through both HDAC-dependent and -independent mechanisms. Interestingly, the presence of oncogenic Ras, which is able to induce premature senescence, increases the p33ING1-mediated silencing function. Moreover, ING1-mediated silencing was reduced by coexpressing dominant-negative Ras or by treatment with the mitogen-activated protein kinase inhibitor PD98059 but not by treatment with SB203580, an inhibitor of the p38 pathway. In addition, we show that both silencing domains of ING1 are involved in cell cycle control, as measured by inhibition of colony formation of immortalized cells and by thymidine incorporation of primary human diploid fibroblasts (HDF). Interestingly, p33ING1 expression induces features of cellular senescence in HDFs.
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