ArticleMolecular and cellular biology2005
Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Identification and characterisation of subtype-specific anti-N-CoR OSGEP protease in acute myeloid leukaemia (AML-M5) cell lineage.Biotechnology letters · 2025Article
- PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia.Molecular medicine reports · 2017Article
- Location of NLS-RARα protein in NB4 cell and nude mice.Oncology letters · 2017Article
- NLS‑RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway.Molecular medicine reports · 2016Article
- Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling.Molecular medicine reports · 2016Article
- NLS-RARα Inhibits the Effects of All-trans Retinoic Acid on NB4 Cells by Interacting with P38α MAPK.International journal of medical sciences · 2016Article
- Neutrophil elastase and its therapeutic effect on leukemia cells.Molecular medicine reports · 2015Article
- The PML domain of PML-RARα blocks senescence to promote leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Synthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells.Journal of medicinal chemistry · 2014Article
- ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.Hematology/oncology clinics of North America · 2013Review
- PML(NLS(-)) inhibits cell apoptosis and promotes proliferation in HL-60 cells.International journal of medical sciences · 2013Article
- Effect of GINS2 on proliferation and apoptosis in leukemic cell line.International journal of medical sciences · 2013Article
- Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.PloS one · 2012Article
- PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.The Journal of clinical investigation · 2011Article
- Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.Blood · 2011Article
- IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ.Nature immunology · 2011Article
- Article
- Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase.Molecular and cellular biology · 2009Article
- PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.Leukemia · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the PML-retinoic acid receptor alpha (PML-RARalpha) fusion protein is the initiating genetic event for acute promyelocytic leukemia (APL), but the molecular mechanisms responsible for disease initiation are not yet clear. Several observations have suggested that early myeloid cells are uniquely susceptible to transformation by PML-RARalpha. Recently, we have shown that the early myeloid-specific protease neutrophil elastase is important for APL development in the mouse. To better understand the role of neutrophil elastase for the pathogenesis of APL, we examined the consequences of PML-RARalpha expression in early myeloid cells with or without neutrophil elastase. We found that high-level PML-RARalpha expression was associated with cellular toxicity that was dependent on the expression of neutrophil elastase; a mutant form of PML-RARalpha that resisted neutrophil elastase cleavage was not toxic. When PML-RARalpha was expressed at very low levels in the early myeloid cells of mice, it induced myeloid expansion and delayed myeloid maturation; neutrophil elastase was also required for these activities. The activities of PML-RARalpha in early myeloid cells are therefore strongly influenced by the presence of neutrophil elastase. To assure physiologic relevance, PML-RARalpha functions should be evaluated in neutrophil elastase-expressing early myeloid cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.