ArticleProceedings of the National Academy of Sciences of the United States of America2004
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 94 citations in OpenAlex.
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- Probing Cell Redox State and Glutathione-Modulating Factors Using a Monochlorobimane-Based Microplate Assay.Antioxidants (Basel, Switzerland) · 2022Article
- Characterization of lapachol cytotoxicity: contribution of glutathione depletion for oxidative stress in Saccharomyces cerevisiae.Folia microbiologica · 2020Article
- Recent Advances in Scanning Electrochemical Microscopy for Biological Applications.Materials (Basel, Switzerland) · 2018Review
- Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring.Scientific reports · 2016Article
- Scientific Opinion on the safety and efficacy of vitamin KEFSA journal. European Food Safety Authority · 2014Article
- Assessment of multidrug resistance on cell coculture patterns using scanning electrochemical microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Inhibition of the MRP1-mediated transport of the menadione-glutathione conjugate (thiodione) in HeLa cells as studied by SECM.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress.Metabolomics : Official journal of the Metabolomic Society · 2012Article
- Imaging enzymes at work: metabolic mapping by enzyme histochemistry.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Review
- The Kv channel blocker 4-aminopyridine enhances Ag+ uptake: a scanning electrochemical microscopy study of single living cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Glucose and lactate biosensors for scanning electrochemical microscopy imaging of single live cells.Analytical chemistry · 2008Article
- Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.Journal of medicinal chemistry · 2008Article
- Nanoelectrochemistry of mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytotoxicity of menadione on hepatocytes was studied by using the substrate generation/tip collection mode of scanning electrochemical microscopy by exposing the cells to menadione and detecting the menadione-S-glutathione conjugate (thiodione) that is formed during the cellular detoxication process and is exported from the cell by an ATP-dependent pump. This efflux was electrochemically detected and allowed scanning electrochemical microscopy monitoring and imaging of single cells and groups of highly confluent live cells. Based on a constant flux model, approximately 6 x 10(6) molecules of thiodione per cell per second are exported from monolayer cultures of Hep G2 cells.
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