ArticleJournal of bacteriology2005
Localization of MreB in Rhodobacter sphaeroides under conditions causing changes in cell shape and membrane structure.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Alanine-scanning mutagenesis library of MreB reveals distinct roles for regulating cell shape and viability.PLoS genetics · 2026Article
- Long-read methylome analysis of Oleidesulfovibrio alaskensis G20 biofilm under copper stress.Scientific reports · 2025Article
- Article
- The role of CenKR in the coordination ofmBio · 2023Article
- A bacterial cytolinker couples positioning of magnetic organelles to cell shape control.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Enhancing single-cell hyaluronic acid biosynthesis by microbial morphology engineering.Synthetic and systems biotechnology · 2020Article
- Cardiolipin AltersmBio · 2019Article
- Status of Targeting MreB for the Development of Antibiotics.Frontiers in chemistry · 2019Review
- Is Longitudinal Division in Rod-Shaped Bacteria a Matter of Swapping Axis?Frontiers in microbiology · 2018Review
- Super-Resolution Microscopy and Single-Protein Tracking in Live Bacteria Using a Genetically Encoded, Photostable Fluoromodule.Current protocols in cell biology · 2017Article
- Metabolism Shapes the Cell.Journal of bacteriology · 2017Review
- Complete genome sequence ofStandards in genomic sciences · 2017Article
- Bacterial morphogenesis and the enigmatic MreB helix.Nature reviews. Microbiology · 2015Article
- Bacterial actin and tubulin homologs in cell growth and division.Current biology : CB · 2015Review
- Modelling and analysis of bacterial tracks suggest an active reorientation mechanism in Rhodobacter sphaeroides.Journal of the Royal Society, Interface · 2014Article
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- Article
- The effect of inhibition of host MreB on the infection of thermophilic phage GVE2 in high temperature environment.Scientific reports · 2014Article
- Image analysis in fluorescence microscopy: bacterial dynamics as a case study.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Review
- A widespread family of bacterial cell wall assembly proteins.The EMBO journal · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MreB is thought to be a bacterial actin homolog that defines the morphology of rod-shaped bacteria. Rhodobacter sphaeroides changes shape, from a rod to coccobacillus, and undergoes extensive cytoplasmic membrane invagination when it switches from aerobic to photoheterotrophic growth. The role of MreB in defining R. sphaeroides shape was therefore investigated. Attempts at deleting or insertionally inactivating mreB were unsuccessful under all growth conditions. Immunofluorescence microscopy showed MreB localized to mid-cell in elongating cells under both aerobic and photoheterotrophic conditions. Three-dimensional reconstruction showed that MreB formed a ring at mid-cell. MreB remained at mid-cell as septation began but localized to new sites in the daughter cells before the completion of septation. MreB localized to putative septation sites in cephalexin-treated filamentous cells. Genomic single-copy mreB was replaced with gfp-mreB, and green fluorescent protein (GFP)-MreB localized in the same pattern, as seen with immunofluorescence microscopy. Some of the cells expressing GFP-MreB were abnormal, principally displaying an increase in cell width, suggesting that the fusion was not fully functional in all cells. GFP-MreB localized to swellings at mid-cell in cells treated with the penicillin-binding protein 2 inhibitor amdinocillin. These data suggest that MreB is essential in R. sphaeroides, performing a role at mid-cell in elongating cells, and in early septation, putatively in the cytoplasmic control of the peptidoglycan synthetic complexes.
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