ArticleHuman genomics2003
Gametic phase estimation over large genomic regions using an adaptive window approach.
Article in Human genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Article
- Contrasting population structure and demographic history of cereal aphids in different environmental and agricultural landscapes.Ecology and evolution · 2020Article
- Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais.The Journal of infectious diseases · 2020Article
- Article
- Low expressionCytokine: X · 2019Article
- Genetic variation of 17 X-chromosome STR loci in Tunisian population of Nabeul.International journal of legal medicine · 2019Article
- A possible genetic basis for vulnerability in Euphydryas maturna (Lepidoptera: Nymphalidae).Genetica · 2017Article
- Historical gene flow constraints in a northeastern Atlantic fish: phylogeography of the ballan wrasseRoyal Society open science · 2017Article
- Article
- Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance.International journal for parasitology · 2017Article
- Differentiation in putative male sex pheromone components across and within populations of the African butterfly Bicyclus anynana as a potential driver of reproductive isolation.Ecology and evolution · 2016Article
- MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.Clinical and experimental immunology · 2016Article
- Establishment of a coastal fish in the Azores: recent colonisation or sudden expansion of an ancient relict population?Heredity · 2015Article
- gPGA: GPU Accelerated Population Genetics Analyses.PloS one · 2015Article
- High intralocus variability and interlocus recombination promote immunological diversity in a minimal major histocompatibility system.BMC evolutionary biology · 2014Article
- HLA-DPB1*04:01 allele is associated with non-obstructive azoospermia in Japanese patients.Human genetics · 2013Article
- Maximum parsimony xor haplotyping by sparse dictionary selection.BMC genomics · 2013Article
- ATP7B variants as modulators of copper dyshomeostasis in Alzheimer's disease.Neuromolecular medicine · 2013Article
- Progressive recombination suppression and differentiation in recently evolved neo-sex chromosomes.Molecular biology and evolution · 2013Article
- Genetic variability in markers of HLA-C expression in two diverse South African populations.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors present ELB, an easy to programme and computationally fast algorithm for inferring gametic phase in population samples of multilocus genotypes. Phase updates are made on the basis of a window of neighbouring loci, and the window size varies according to the local level of linkage disequilibrium. Thus, ELB is particularly well suited to problems involving many loci and/or relatively large genomic regions, including those with variable recombination rate. The authors have simulated population samples of single nucleotide polymorphism genotypes with varying levels of recombination and marker density, and find that ELB provides better local estimation of gametic phase than the PHASE or HTYPER programs, while its global accuracy is broadly similar. The relative improvement in local accuracy increases both with increasing recombination and with increasing marker density. Short tandem repeat (STR, or microsatellite) simulation studies demonstrate ELB's superiority over PHASE both globally and locally. Missing data are handled by ELB; simulations show that phase recovery is virtually unaffected by up to 2 per cent of missing data, but that phase estimation is noticeably impaired beyond this amount. The authors also applied ELB to datasets obtained from random pairings of 42 human X chromosomes typed at 97 diallelic markers in a 200 kb low-recombination region. Once again, they found ELB to have consistently better local accuracy than PHASE or HTYPER, while its global accuracy was close to the best.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.