ReviewZeitschrift fur Kardiologie2004
Sitosterolemia--a rare disease. Are elevated plant sterols an additional risk factor?
Review in Zeitschrift fur Kardiologie, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies.The British journal of nutrition · 2014Pooled it
- The effect of a low-fat spread with added plant sterols on vascular function markers: results of the Investigating Vascular Function Effects of Plant Sterols (INVEST) study.The American journal of clinical nutrition · 2015Trial
- Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds.Nutrition journal · 2014Trial
- Serum lipids, plant sterols, and cholesterol kinetic responses to plant sterol supplementation in phytosterolemia heterozygotes and control individuals.The American journal of clinical nutrition · 2012Trial
- Baseline plasma plant sterol concentrations do not predict changes in serum lipids, C-reactive protein (CRP) and plasma plant sterols following intake of a plant sterol-enriched food.European journal of clinical nutrition · 2009Trial
- Phytosterols and Cardiovascular Risk Evaluated against the Background of Phytosterolemia Cases-A German Expert Panel Statement.Nutrients · 2023Article
- Review
- Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice.Scientific reports · 2021Article
- Stigmasterol accumulation causes cardiac injury and promotes mortality.Communications biology · 2019Article
- Progress and perspectives in plant sterol and plant stanol research.Nutrition reviews · 2018Review
- Plant sterol enriched functional food and atherosclerosis.British journal of pharmacology · 2017Review
- ABCG transporters and disease.The FEBS journal · 2011Review
- Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice.Cardiovascular research · 2011Article
- Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet.Lipids in health and disease · 2009Article
- Free and glycosylated sterol bioaccumulation in developing Cycas micronesica seeds.Food chemistry · 2009Article
- Controversial role of plant sterol esters in the management of hypercholesterolaemia.European heart journal · 2009Article
- Phenotypic Characteristics as Predictors of Phytosterols in Mature Cycas micronesica Seeds.HortScience : a publication of the American Society for Horticultural Science · 2009Article
- Plant Sterols, Stanols, and Sitosterolemia.Journal of AOAC InternationalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated plasma plant sterol concentrations, xanthomatosis, and accelerated-often fatal-atherosclerosis at young age are the major findings in patients with homozygous sitosterolemia. A defect in the ABCG5 or ABCG8 co-transporter gene locus (STSL) causes an increased intestinal absorption and a decreased biliary elimination of all sterols, plant sterols as well as cholesterol, leading to a 50 to 200-fold increase in plasma plant sterol concentrations. A few recent publications indicate that even moderately elevated plasma plant sterol levels might be associated with an increased risk of atherosclerosis. This raises the question whether plant sterols themselves might be atherogenic or whether elevated plasma levels are a marker for a decreased ABCG5/G8 transporter activity which itself causes an increased risk for atherosclerosis. However, current data are too few to conclude that elevated plant sterol concentrations in plasma are an additional risk factor for coronary heart disease. But especially young patients suffering from xanthomatosis and/or atherosclerotic diseases with only mildly or moderately elevated plasma cholesterol should be screened for sitosterolemia by measurement of plasma plant sterol levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.