Trial reportEuropean journal of nuclear medicine and molecular imaging2005
Physiological 18F-FDG uptake in the ovaries and uterus of healthy female volunteers.
Trial report in European journal of nuclear medicine and molecular imaging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Ovarian cancer staging and follow-up: updated guidelines from the European Society of Urogenital Radiology female pelvic imaging working group.European radiology · 2025Guideline
- Cutaneous Malignancies Metastatic to the Female Genital Tract and Pelvic Lymph Nodes: Analysis of Metastatic Patterns and Pathogenesis.Journal of clinical medicine · 2026Review
- Physiological Uptake ofMolecular imaging and biology · 2025Article
- The frequency and characterization of ovarian metastasis from nonovarian cancers using 18F-fluorodeoxyglucose PET/CT.BJR open · 2025Article
- The effect of hormone therapy on physiological uptake of the endometrium on [Annals of nuclear medicine · 2024Article
- Application of PET/MRI in Gynecologic Malignancies.Cancers · 2024Review
- Comparative assessment of the diagnostic efficacy of [Frontiers in oncology · 2024Article
- An evaluation of the physiological uptake range ofFrontiers in veterinary science · 2024Article
- Modulation of Secondary Cancer Risks from Radiation Exposure by Sex, Age and Gonadal Hormone Status: Progress, Opportunities and Challenges.Journal of personalized medicine · 2022Review
- Article
- The role of CT, PET-CT, and MRI in ovarian cancer.The British journal of radiology · 2021Review
- Article
- Physiologic and hypermetabolic breast 18-F FDG uptake on PET/CT during lactation.European radiology · 2021Article
- Clinical Etiology of Hypermetabolic Pelvic Lesions in Postoperative Positron Emission Tomography/Computed Tomography for Patients With Rectal and Sigmoid Cancer.Annals of coloproctology · 2018Article
- Evidence-based management of incidental focal uptake of fluorodeoxyglucose on PET-CT.The British journal of radiology · 2018Review
- Analysis of positron emission tomography/computed tomography in patients to differentiate between malignant transformation of endometrioma and endometrioma.International journal of clinical oncology · 2016Article
- Primary Uterine Peripheral T-cell Lymphoma: A Case Report of MRI and 18F-FDG PET/CT Findings.Medicine · 2016Article
- Present and future role of FDG-PET/CT imaging in the management of gynecologic malignancies.Japanese journal of radiology · 2014Review
- A rare presentation of lymphoma of the cervix with cross-sectional imaging correlation.Case reports in radiology · 2014Article
- Multimodality imaging of ovarian cystic lesions: Review with an imaging based algorithmic approach.World journal of radiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGood knowledge of physiological 18F-fluorodeoxglucose (18F-FDG) uptake in the healthy population is of great importance for the correct interpretation of 18F-FDG positron emission tomography (PET) images of pathological processes. The purpose of this study was to investigate the physiological 18F-FDG uptake in the ovaries and uterus of healthy female volunteers.
methodsOne hundred and 33 healthy females, 78 of whom were premenopausal (age 37.2+/-6.9 years) and 55 postmenopausal (age 55.0+/-2.7 years), were examined using whole-body 18F-FDG PET and pelvic magnetic resonance (MR) imaging. Focal 18F-FDG uptake in the ovaries and uterus was evaluated visually and using standardised uptake value (SUVs). Anatomical and morphological information was obtained from MR images.
resultsDistinct ovarian 18F-FDG uptake with an SUV of 3.9+/-0.7 was observed in 26 premenopausal women out of 32 examined during the late follicular to early luteal phase of the menstrual cycle. Eighteen of the 32 women also showed focal 18F-FDG uptake in the endometrium, with an SUV of 3.3+/-0.3. On the other hand, all nine women in the first 3 days of the menstrual cycle demonstrated intense 18F-FDG uptake in the endometrium, with an SUV of 4.6+/-1.0. No physiological 18F-FDG uptake was observed in the ovaries or uterus of any postmenopausal women.
conclusionIn women of reproductive age, 18F-FDG imaging should preferably be done within a week before or a few days after the menstrual flow phase to avoid any misinterpretation of pelvic 18F-FDG PET images.
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