ArticleJournal of molecular evolution2004
Molecular evolution of the hepatitis delta virus antigen gene: recombination or positive selection?
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Characterizing Physicochemical Selection in Protein Evolution with Property-Informed Models (PRIME).bioRxiv : the preprint server for biology · 2026Article
- Prevalence and VP1 Gene Evaluation Analysis of Porcine Sapelovirus in Yunnan Province, China, from 2024 to 2025.Viruses · 2025Article
- Seed protein electrophoresis in plant genetics: Commemorating the pioneering contributions of Prof. Chittaranjan Kole and team to the foundation of plant proteomics.The plant genome · 2025Review
- Evolutionary Shortcuts via Multinucleotide Substitutions and Their Impact on Natural Selection Analyses.Molecular biology and evolution · 2023Article
- Constraint of Base Pairing on HDV Genome Evolution.Viruses · 2021Article
- Novel hepatitis D-like agents in vertebrates and invertebrates.Virus evolution · 2019Article
- Host RNA circles and the origin of hepatitis delta virus.World journal of gastroenterology · 2014Review
- Prevalence of hepatitis delta virus (HDV) infection in chronic hepatitis B patients with unusual clinical pictures.Hepatitis monthly · 2013Article
- Evolution and diversity of the human hepatitis d virus genome.Advances in bioinformatics · 2010Article
- Phylogenetic analyses: A toolbox expanding towards Bayesian methods.International journal of plant genomics · 2008Article
- Computational analysis and identification of amino acid sites in dengue E proteins relevant to development of diagnostics and vaccines.Virus genes · 2007Article
- Positive selection of hepatitis delta antigen in chronic hepatitis D patients.Journal of virology · 2007Article
- Positively selected codons in immune-exposed loops of the vaccine candidate OMP-P1 of Haemophilus influenzae.Journal of molecular evolution · 2007Article
- Positive selection on transposase genes of insertion sequences in the Crocosphaera watsonii genome.Journal of bacteriology · 2006Article
- Positive and negative selection in the beta-esterase gene cluster of the Drosophila melanogaster subgroup.Journal of molecular evolution · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the statistical analysis of diversifying selective pressures on the hepatitis D antigen gene (HDAg). Thirty-three distinct HDAg sequences from subtypes I, II, and III were tested for positive selection using maximum likelihood methods based on models of codon substitution that allow variable selective pressures across sites. Such methods have been shown to be sufficiently accurate and successful in detecting positive selection in a variety of viral and nonviral protein-coding genes. About 11% of codon sites in HDAg were estimated to be under diversifying selection. Remarkably, most of the residues predicted to evolve under positive selection were located in the immunogenic domain and the N-terminus region with reported antigenic activity. These sites are potential targets of the host's immune response. Identification of residues mutating to escape immune recognition may help to distinguish the most virulent strains and aid vaccine design. Possible interplay between positive selection and recombination on the gene is discussed but no significant evidence for recombination was found.
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Registered trials
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