ArticleJournal of molecular evolution2004
Phylogenetic analysis of the complete genome sequence of Encephalitozoon cuniculi supports the fungal origin of microsporidia and reveals a high frequency of fast-evolving genes.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 141 citations in OpenAlex.
- Stable transformation of fluorescent proteins into Nosema bombycis by electroporation.Parasites & vectors · 2022Article
- Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota.Nature communications · 2021Article
- Identification and characterization a novel polar tube protein (NbPTP6) from the microsporidian Nosema bombycis.Parasites & vectors · 2020Article
- The Evolutionary Traceability of a Protein.Genome biology and evolution · 2019Article
- Evolutionary Genomics of Metchnikovella incurvata (Metchnikovellidae): An Early Branching Microsporidium.Genome biology and evolution · 2018Article
- A genome Tree of Life for the Fungi kingdom.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Comparative genomics of microsporidian genomes reveals a minimal non-coding RNA set and new insights for transcription in minimal eukaryotic genomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- The role of microsporidian polar tube protein 4 (PTP4) in host cell infection.PLoS pathogens · 2017Article
- Genomic Survey of a Hyperparasitic Microsporidian Amphiamblys sp. (Metchnikovellidae).Genome biology and evolution · 2017Article
- Microsporidia-Emergent Pathogens in the Global Food Chain (Trends in Parasitology 32, 336-348; April 2, 2016).Trends in parasitology · 2016Article
- Microsporidia - Emergent Pathogens in the Global Food Chain.Trends in parasitology · 2016Review
- Subtelomere organization in the genome of the microsporidian Encephalitozoon cuniculi: patterns of repeated sequences and physicochemical signatures.BMC genomics · 2016Article
- Microsporidiosis in Vertebrate Companion Exotic Animals.Journal of fungi (Basel, Switzerland) · 2015Review
- Interaction and assembly of two novel proteins in the spore wall of the microsporidian species Nosema bombycis and their roles in adherence to and infection of host cells.Infection and immunity · 2015Article
- Population Genetics of Nosema apis and Nosema ceranae: One Host (Apis mellifera) and Two Different Histories.PloS one · 2015Article
- The Prediction and Validation of Small CDSs Expand the Gene Repertoire of the Smallest Known Eukaryotic Genomes.PloS one · 2015Article
- A monoclonal antibody that tracks endospore formation in the microsporidium Nosema bombycis.PloS one · 2015Article
- Article
- SWP5, a spore wall protein, interacts with polar tube proteins in the parasitic microsporidian Nosema bombycis.Eukaryotic cell · 2012Article
- Annotation of microsporidian genomes using transcriptional signals.Nature communications · 2012Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsporidia are unicellular eukaryotes living as obligate intracellular parasites. Lacking mitochondria, they were initially considered as having diverged before the endosymbiosis at the origin of mitochondria. That microsporidia were primitively amitochondriate was first questioned by the discovery of microsporidial sequences homologous to genes encoding mitochondrial proteins and then refuted by the identification of remnants of mitochondria in their cytoplasm. Various molecular phylogenies also cast doubt on the early divergence of microsporidia, these organisms forming a monophyletic group with or within the fungi. The 2001 proteins putatively encoded by the complete genome of Encephalitozoon cuniculi provided powerful data to test this hypothesis. Phylogenetic analysis of 99 proteins selected as adequate phylogenetic markers indicated that the E. cuniculi sequences having the lowest evolutionary rates preferentially clustered with fungal sequences or, more rarely, with both animal and fungal sequences. Because sequences with low evolutionary rates are less sensitive to the long-branch attraction artifact, we concluded that microsporidia are evolutionarily related to fungi. This analysis also allowed comparing the accuracy of several phylogenetic algorithms for a fast-evolving lineage with real rather than simulated sequences.
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