ReviewThe Journal of clinical investigation2004
TB, or not TB: that is the question -- does TLR signaling hold the answer?
Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Polymorphism in the TLR Adaptors of the Toll Signalling Pathway for Use in Livestock Breeding for Health Traits.International journal of molecular sciences · 2026Review
- Role of pattern recognition receptors in sensingHeliyon · 2023Review
- Nicotine Modulates MyD88-Dependent Signaling Pathway in Macrophages during Mycobacterial Infection.Microorganisms · 2020Article
- Article
- microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways.Immune network · 2019Review
- Identification of genes associated with susceptibility to Mycobacterium avium ssp. paratuberculosis (Map) tissue infection in Holstein cattle using gene set enrichment analysis-SNP.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Admixture mapping of tuberculosis and pigmentation-related traits in an African-European hybrid cattle population.Frontiers in genetics · 2015Article
- Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology.Mediators of inflammation · 2015Review
- Analysis of Toll-like receptors, iNOS and cytokine profiles in patients with pulmonary tuberculosis during anti-tuberculosis treatment.PloS one · 2014Article
- The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis.Genes and immunity · 2013Article
- Heterozygosity at the A625C polymorphic site of the MyD88 gene is associated with Mycobacterium bovis infection in cattle.Infection and immunity · 2013Article
- Mycobacterial signaling through toll-like receptors.Frontiers in cellular and infection microbiology · 2012Review
- Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes.BMC genomics · 2011Article
- Tuberculosis immunity: opportunities from studies with cattle.Clinical & developmental immunology · 2011Review
- Toll-like receptors in innate immunity and infectious diseases.Frontiers of medicine in China · 2010Review
- RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.Cell host & microbe · 2009Article
- Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program.BMC genomics · 2008Article
- Disifin (sodium tosylchloramide) and Toll-like receptors (TLRs): evolving importance in health and diseases.Journal of industrial microbiology & biotechnology · 2007Review
- Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease.BMC genomics · 2007Article
- The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis.BMC infectious diseases · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Innate immunity critically depends on signaling by Toll-like receptors (TLRs) that rely heavily on an intracellular adapter protein called myeloid differentiation factor 88 (MyD88). Adaptive immune defenses are generally thought to be orchestrated by innate immune responses and so should require intact TLR-MyD88 signaling pathways. But a surprising new study in MyD88-null mice infected with Mycobacterium tuberculosis challenges this view and instead suggests that MyD88 may not be absolutely required for a normal adaptive immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.