Evidence map›Paper›PMID 15599393›Full record

ReviewThe Journal of clinical investigation2004

Acid sensing in renal epithelial cells.

Stephen L Gluck

Open access · bronzeAbstract readReviewComment
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Transcriptional regulation of the pendrin gene.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2011
    Review
  3. Physiological carbon dioxide, bicarbonate, and pH sensing.Pflugers Archiv : European journal of physiology · 2010
    Review
  4. Deletion of the pH sensor GPR4 decreases renal acid excretion.Journal of the American Society of Nephrology : JASN · 2010
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Stephen L GluckDivision of Nephrology, UCSF, 513 Parnassus Avenue, Box 0532, San Francisco, California 94143-0532, USA. glucks1@medicine.ucsf.edu
University of California San Francisco Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.

Indexed as

AnimalsCell LineCytosolEnzyme ActivationEpithelial CellsFocal Adhesion Kinase 2HumansHydrogen-Ion ConcentrationKidneyKineticsModels, BiologicalPhosphorylationProtein BindingProtein ConformationProtein-Tyrosine KinasesProto-Oncogene MasFocal Adhesion Kinase 2MAS1 protein, humanProtein-Tyrosine KinasesProto-Oncogene MasSodium-Hydrogen Exchanger 3Sodium-Hydrogen Exchangerssrc-Family Kinases

Identifiers

PMID15599393
PMCPMC535075
OpenAlexW2004291447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.