SynthesisMolecular psychiatry2005
Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis.
Synthesis in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- Pooled it
- The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review.Drug and alcohol dependence · 2010Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Pooled it
- Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis.Biological psychiatry · 2008Pooled it
- Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis.Molecular psychiatry · 2005Pooled it
- Moderating Effects of Genetic Polymorphisms on Improvements in Cognitive Impairment in Breast Cancer Survivors Participating in a 6-Week Mindfulness-Based Stress Reduction Program.Biological research for nursing · 2015Trial
- Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces.Psychopharmacology · 2005Trial
- Loudness dependence of auditory evoked potentials reflects trait anxiety and harm avoidance in healthy adults: an exploratory study.Frontiers in human neuroscience · 2025Article
- Association between life-ever gallstones and depressive symptoms in U.S. adults: a cross-sectional study.Scientific reports · 2024Article
- Predicting anxiety-related personality traits by means of serotonergic VNTR variants STin2 and 5-HTTLPR.Journal of mood and anxiety disorders · 2023Article
- The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.Brain sciences · 2023Review
- Reaction to norm transgressions and Islamization threat in culturally tight and loose contexts: a cross-cultural comparison of Germany versus Russia.Culture and brain · 2020Article
- Article
- Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Why to cooperate is better than to compete: brain and personality components.BMC neuroscience · 2017Article
- Genetic variation of dopamine and serotonin function modulates the feedback-related negativity during altruistic punishment.Scientific reports · 2017Article
- Early Life Stress, Mood, and Anxiety Disorders.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.Journal of neuroscience research · 2017Review
- Brains in Competition: Improved Cognitive Performance and Inter-Brain Coupling by Hyperscanning Paradigm with Functional Near-Infrared Spectroscopy.Frontiers in behavioral neuroscience · 2017Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We attempted to replicate the findings of two recent meta-analyses that personality inventory moderates the association between the serotonin transporter gene and anxiety-related traits. A total of 24 studies contributed to the meta-analysis, of which three reported genotype frequencies that deviated from Hardy-Weinberg (HW) equilibrium. We found some support for the view that results depend on the type of questionnaire used, although in a direction opposite to that previously reported. Contrasts between the S/S and L/L groups were significant for TCI/TPQ harm avoidance studies (P=0.0024) but not NEO neuroticism (P=0.9757). When studies not in HW equilibrium were excluded the TCI/TPQ result for the S/S genotype still exceeded our 5% threshold, although with reduced significance (P=0.0082), and the NEO result remained nonsignificant (P=0.9109). While we cannot rule out an association between the 5HTT gene and anxiety-related traits, particularly for TCI/TPQ harm avoidance, our findings do indicate that the effect, if present, is small. Our results emphasise the importance of complete ascertainment of studies and the identification of relevant sources of heterogeneity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.