ArticleThe Journal of clinical endocrinology and metabolism2005
Irregular and frequent cortisol secretory episodes with preserved diurnal rhythmicity in primary adrenal Cushing's syndrome.
Article in The Journal of clinical endocrinology and metabolism, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Does somatostatin have a role in the regulation of cortisol secretion in primary pigmented nodular adrenocortical disease (ppnad)? a clinical and in vitro investigation.The Journal of clinical endocrinology and metabolism · 2014Trial
- "Feeding the Rhythm"-Effects of Food and Nutrients on Daily Cortisol Secretion: From Molecular Mechanisms to Clinical Impact.International journal of molecular sciences · 2025Review
- Dynamic Hormone Control of Stress and Fertility.Frontiers in physiology · 2020Article
- Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity.Clinical endocrinology · 2018Article
- The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids.Endocrine reviews · 2017Review
- The landscape of bilateral adrenal incidentalomas associated with subclinical hypercortisolism.Endocrine · 2016Article
- Role of ACTH in the Interactive/Paracrine Regulation of Adrenal Steroid Secretion in Physiological and Pathophysiological Conditions.Frontiers in endocrinology · 2016Review
- Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism.Frontiers in endocrinology · 2015Review
- Prolactin secretion in healthy adults is determined by gender, age and body mass index.PloS one · 2012Article
- Pituitary-hormone secretion by thyrotropinomas.Pituitary · 2009Article
- Motivations and methods for analyzing pulsatile hormone secretion.Endocrine reviews · 2008Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
To evaluate the pathophysiology of altered cortisol secretion in patients with primary adrenal hypercortisolism, cortisol secretion was investigated in 12 patients, seven with a unilateral adenoma and five with ACTH-independent macronodular adrenal hyperplasia compared with age- and gender-matched controls and with patients with pituitary-dependent hypercortisolism. Pulsatile secretion was increased 2-fold (P = 0.04), attributable to increased event frequency (P = 0.002). All patients showed a significant diurnal rhythm with a delay in phase shift of 3 h (P = 0.01). Approximate entropy ratio, a feedback-sensitive measure, was increased compared with controls (P = 0.00003) but similar to that of pituitary-dependent hypercortisolism (P = 0.77), denoting loss of autoregulation. Cortisol burst-mass tended to be smaller in patients with ACTH-independent macronodular adrenal hyperplasia than in unilateral adenoma (P = 0.06). In conclusion, increased cortisol secretion in patients with primary adrenal Cushing's syndrome is caused by amplified pulsatile secretion via event frequency modulation. We speculate that partial preservation of secretory regularity and diurnal rhythmicity point to incomplete autonomy of these tumors.
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Registered trials
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