ArticleEnvironmental health perspectives2004
Renal toxicogenomic response to chronic uranyl nitrate insult in mice.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Reference genes for proximal femoral epiphysiolysis expression studies in broilers cartilage.PloS one · 2020Article
- Transcriptomics in toxicology.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Review
- Uranium XAFS analysis of kidney from rats exposed to uranium.Journal of synchrotron radiation · 2017Article
- Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury.Clinical kidney journal · 2015Review
- Identification of gene co-expression clusters in liver tissues from multiple porcine populations with high and low backfat androstenone phenotype.BMC genetics · 2015Article
- Hepatic transcriptomic profiling reveals early toxicological mechanisms of uranium in Atlantic salmon (Salmo salar).BMC genomics · 2014Article
- Mitochondrial toxicity of depleted uranium: protection by Beta-glucan.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Uranyl acetate induces oxidative stress and mitochondrial membrane potential collapse in the human dermal fibroblast primary cells.Iranian journal of pharmaceutical research : IJPR · 2012Article
- Health effects of naturally radioactive water ingestion: the need for enhanced studies.Environmental health perspectives · 2011Review
- Concentration of metals in blood of Maine children 1-6 years old.Journal of exposure science & environmental epidemiology · 2010Article
- Development of risk maps to minimize uranium exposures in the Navajo Churchrock mining district.Environmental health : a global access science source · 2009Article
- Feeding mice with diets containing mercury-contaminated fish flesh from French Guiana: a model for the mercurial intoxication of the Wayana Amerindians.Environmental health : a global access science source · 2008Article
- cDNA cloning and overexpression of acidic ribosomal phosphoprotein P1 gene (RPLP1) from the giant panda.International journal of biological sciences · 2007Article
- Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure.BMC genomics · 2006Article
- In vitro immune toxicity of depleted uranium: effects on murine macrophages, CD4+ T cells, and gene expression profiles.Environmental health perspectives · 2006Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the nephrotoxicity of uranium has been established through numerous animal studies, relatively little is known about the effects of long-term environmental uranium exposure. Using a combination of conventional biochemical studies and serial analysis of gene expression (SAGE), we examined the renal responses to uranyl nitrate (UN) chronic exposure. Renal uranium levels were significantly increased 4 months after ingestion of uranium in drinking water. Creatinine levels in serum were slightly but significantly increased compared with those in controls. Although no further significant differences in other parameters were noted, substantial molecular changes were observed in toxicogenomic profiles. UN induced dramatic alterations in expression levels of more than 200 genes, mainly up-regulated, including oxidative-response-related genes, genes encoding for cellular metabolism, ribosomal proteins, signal transduction, and solute transporters. Seven differentially expressed transcripts were confirmed by real-time quantitative polymerase chain reaction. In addition, significantly increased peroxide levels support the implication of oxidative stress in UN toxicant response. This report highlights the potential of SAGE for the discovery of novel toxicant-induced gene expression alterations. Here, we present, for the first time, a comprehensive view of renal molecular events after uranium long-term exposure.
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