Evidence map›Paper›PMID 15596858›Full record

ArticleJournal of virology2005

Comparative immunogenicity of human immunodeficiency virus particles and corresponding polypeptides in a DNA vaccine.

Wataru Akahata, Zhi-yong Yang, Gary J Nabel

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wataru AkahataVaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892-3005, USA.
Zhi-yong Yang
Gary J Nabel
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

HIV/AIDS Vaccine DevelopmentZIAAI005002 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MASCOLA, JOHN · 2009 to 2018
$50.9M
HIV/AIDS Vaccine DevelopmentZ01AI005002 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI NABEL, GARY J · 2002 to 2008
$3.5M
Understanding adenoviral structure and mechanisms of entry into cellsZ01AI005076 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI NABEL, GARY J · 2005 to 2007
$296k
6 · The paper itself

Abstract

The immunogenicity of a plasmid DNA expression vector encoding both Gag and envelope (Env), which produced human immunodeficiency virus (HIV) type 1 virus-like particles (VLP), was compared to vectors expressing Gag and Env individually, which presented the same gene products as polypeptides. Vaccination with plasmids that generated VLP showed cellular immunity comparable to that of Gag and cell-mediated or humoral responses similar to those of Env as immunization with separate vectors. These data suggest that DNA vaccines encoding separated HIV polypeptides generate immune responses similar to those generated by viral particles.

Indexed as

AIDS VaccinesAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleGene Products, envGene Products, gagHIV-1HIV AntibodiesHIV InfectionsHumansImmunizationMiceMice, Inbred BALB CPeptidesVaccines, DNAAIDS VaccinesGene Products, envGene Products, gagHIV AntibodiesPeptidesVaccines, DNA

Identifiers

PMID15596858
PMCPMC538686
OpenAlexW2008104951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.