ArticleJournal of virology2005
Expression of cellular oncogene Bcl-xL prevents coronavirus-induced cell death and converts acute infection to persistent infection in progenitor rat oligodendrocytes.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- AnJournal of virology · 2024Article
- ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease.Frontiers in cellular neuroscience · 2014Review
- Review
- Article
- Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5.Journal of virology · 2010Article
- CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination.PloS one · 2010Article
- The pathogenesis of murine coronavirus infection of the central nervous system.Critical reviews in immunology · 2010Review
- The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System.Current immunology reviews · 2009Article
- Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronaviruses.Cellular microbiology · 2007Review
- Murine coronavirus-induced oligodendrocyte apoptosis is mediated through the activation of the Fas signaling pathway.Virology · 2007Article
- Induction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection.Virology · 2006Article
- Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis.Journal of virology · 2006Article
- Persistent coronavirus infection of progenitor oligodendrocytes.Advances in experimental medicine and biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Murine coronavirus mouse hepatitis virus (MHV) causes persistent infection of the central nervous system (CNS) in rodents, which has been associated with demyelination. However, the precise mechanism of MHV persistence in the CNS remains elusive. Here we show that the progenitor oligodendrocytes (central glial 4 [CG-4] cells) derived from newborn rat brain were permissive to MHV infection, which resulted in cell death, although viral replication was restricted. Interestingly, treatment with fetal bovine serum or exogenous expression of cellular oncogene Bcl-xL prevented CG-4 cells from MHV-induced cell death. Significantly, overexpression of Bcl-xL alone was sufficient to convert acute to persistent, nonproductive infection in CG-4 cells. This finding indicates that intracellular factors rather than viral components play a critical role in establishing viral persistence in CNS cells. Although viral genomic RNAs continuously persisted in Bcl-xL-expressing CG-4 cells over 10 passages, infectious virus could no longer be isolated beyond 2 passages of the cell. Such a phenomenon resembles the persistent MHV infection in animal CNS. Thus, the establishment of a persistent, nonproductive infection in CG-4 cells may provide a useful in vitro model for studying viral persistence in animal CNS. The data also suggest that direct virus-host cell interaction is one of the underlying mechanisms that regulate viral persistence in CNS cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.