ArticleProceedings of the National Academy of Sciences of the United States of America2004
Adaptive evolution of cytochrome c oxidase: Infrastructure for a carnivorous plant radiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Recombination and Retroprocessing in Broomrapes Reveal RNA-Mediated Gene Transfer Mechanism and a Generalizable Model for Mitochondrial Evolution in Heterotrophic Plants.Genome biology and evolution · 2026Article
- High metabolic rates drive tiny genomes in plants (and birds): a commentary on 'The smallest angiosperm genomes may be the price for effective traps of bladderworts'.Annals of botany · 2024Article
- The smallest angiosperm genomes may be the price for effective traps of bladderworts.Annals of botany · 2024Article
- Alternative or cytochrome? Respiratory pathways in traps of aquatic carnivorous bladderwortPlant signaling & behavior · 2022Article
- Biogeographical patterns and speciation of the genus Pinguicula (Lentibulariaceae) inferred by phylogenetic analyses.PloS one · 2021Article
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- A phylogenetic analysis of macroevolutionary patterns in fermentative yeasts.Ecology and evolution · 2016Article
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- Fastest predators in the plant kingdom: functional morphology and biomechanics of suction traps found in the largest genus of carnivorous plants.AoB PLANTS · 2015Article
- A novel insight into the cost-benefit model for the evolution of botanical carnivory.Annals of botany · 2015Review
- Transcriptome and genome size analysis of the Venus flytrap.PloS one · 2015Article
- Introgression of mitochondrial DNA promoted by natural selection in the Japanese pipistrelle bat (Pipistrellus abramus).Genetica · 2014Article
- Evolution of genome size and chromosome number in the carnivorous plant genus Genlisea (Lentibulariaceae), with a new estimate of the minimum genome size in angiosperms.Annals of botany · 2014Article
- Polar bears exhibit genome-wide signatures of bioenergetic adaptation to life in the arctic environment.Genome biology and evolution · 2014Article
- Quite a few reasons for calling carnivores 'the most wonderful plants in the world'.Annals of botany · 2012Review
- Transcriptomics and molecular evolutionary rate analysis of the bladderwort (Utricularia), a carnivorous plant with a minimal genome.BMC plant biology · 2011Article
- The smallest but fastest: ecophysiological characteristics of traps of aquatic carnivorous Utricularia.Plant signaling & behavior · 2011Review
- Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans.PLoS pathogens · 2010Article
- Feeding enhances photosynthetic efficiency in the carnivorous pitcher plant Nepenthes talangensis.Annals of botany · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Much recent attention in the study of adaptation of organismal form has centered on developmental regulation. As such, the highly conserved respiratory machinery of eukaryotic cells might seem an unlikely target for selection supporting novel morphologies. We demonstrate that a dramatic molecular evolutionary rate increase in subunit I of cytochrome c oxidase (COX) from an active-trapping lineage of carnivorous plants is caused by positive Darwinian selection. Bladderworts (Utricularia) trap plankton when water-immersed, negatively pressured suction bladders are triggered. The resetting of traps involves active ion transport, requiring considerable energy expenditure. As judged from the quaternary structure of bovine COX, the most profound adaptive substitutions are two contiguous cysteines absent in approximately 99.9% of databased COX I sequences from Eukaryota, Archaea, and Bacteria. This motif lies directly at the docking point of COX I helix 3 and cytochrome c, and modeling of bovine COX I suggests the possibility of an unprecedented helix-terminating disulfide bridge that could alter COX/cytochrome c dissociation kinetics. Thus, the key adaptation in Utricularia likely lies in molecular energetic changes that buttressed the mechanisms responsible for the bladderworts' radical morphological evolution. Along with evidence for COX evolution underlying expansion of the anthropoid neocortex, our findings underscore that important morphological and physiological innovations must often be accompanied by specific adaptations in proteins with basic cellular functions.
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