ArticleBiophysical journal2005
Creep function of a single living cell.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed.
- TheMaterials today. Bio · 2026Review
- Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells.Biophysical journal · 2025Article
- Cellular and Nuclear Forces: An Overview.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Deformation under flow and morphological recovery of cancer cells.Lab on a chip · 2024Article
- Beyond stiffness: Multiscale viscoelastic features as biomechanical markers for assessing cell types and states.Biophysical journal · 2024Article
- Catch bond kinetics are instrumental to cohesion of fire ant rafts under load.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantitative comparison of cell-cell detachment force in different experimental setups.The European physical journal. E, Soft matter · 2024Article
- SEMAPL bioengineering · 2023Article
- A comprehensive model ofeLife · 2023Article
- Phase separation and ripening in a viscoelastic gel.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A computational model for the transit of a cancer cell through a constricted microchannel.Biomechanics and modeling in mechanobiology · 2023Article
- Myosin and [Formula: see text]-actinin regulation of stress fiber contractility under tensile stress.Scientific reports · 2023Article
- Phenotyping polarization dynamics of immune cells using a lipid droplet-cell pairing microfluidic platform.Cell reports methods · 2022Article
- Network dynamics of the nonlinear power-law relaxation of cell cortex.Biophysical journal · 2022Article
- Viscoelastic properties of suspended cells measured with shear flow deformation cytometry.eLife · 2022Article
- Review
- Frequency-dependent transition in power-law rheological behavior of living cells.Science advances · 2022Article
- Characterization of the Elasticity of CD4Bio-protocol · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- An In Vitro Model System to Test Mechano-Microbiological Interactions Between Bacteria and Host Cells.Methods in molecular biology (Clifton, N.J.) · 2022Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used a novel uniaxial stretching rheometer to measure the creep function J(t) of an isolated living cell. We show, for the first time at the scale of the whole cell, that J(t) behaves as a power-law J(t) = At(alpha). For N = 43 mice myoblasts (C2-7), we find alpha = 0.24 +/- 0.01 and A = (2.4 +/- 0.3) 10(-3) Pa(-1) s(-alpha). Using Laplace Transforms, we compare A and alpha to the parameters G(0) and beta of the complex modulus G*(omega) = G(0)omega(beta) measured by other authors using magnetic twisting cytometry and atomic force microscopy. Excellent agreement between A and G(0) on the one hand, and between alpha and beta on the other hand, indicated that the power-law is an intrinsic feature of cell mechanics and not the signature of a particular technique. Moreover, the agreement between measurements at very different size scales, going from a few tens of nanometers to the scale of the whole cell, suggests that self-similarity could be a central feature of cell mechanical structure. Finally, we show that the power-law behavior could explain previous results first interpreted as instantaneous elasticity. Thus, we think that the living cell must definitely be thought of as a material with a large and continuous distribution of relaxation time constants which cannot be described by models with a finite number of springs and dash-pots.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.