ArticleWorld journal of surgery2004
Andrenocortical carcinomas: twelve-year prospective experience.
Article in World journal of surgery, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Management of adrenocortical carcinoma: a consensus statement of the Italian Society of Endocrinology (SIE).Journal of endocrinological investigation · 2016Guideline
- Ectopic Adrenocortical Cancer Originating From the Pancreas: A Case Report With Literature Review.International journal of surgical pathology · 2026Review
- Characteristics of adrenocortical carcinoma in South Korea: a registry-based nationwide survey.Endocrine connections · 2020Article
- Giant nonfunctional ectopic adrenocortical carcinoma on the anterior abdominal wall: A case report.World journal of clinical cases · 2019Article
- Efficacy of oral metformin in a patient with metastatic adrenocortical carcinoma: Examination of mechanisms and therapeutic implications.Rare tumors · 2018Article
- A Rare Presentation of Infantile Virilization Secondary to Malignant Etiology.Indian journal of surgical oncology · 2017Article
- Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature.Oncology letters · 2016Article
- Survival and prognostic factors for adrenocortical carcinoma: a single institution experience.BMC urology · 2015Article
- Malignant Perivascular Epithelioid Cell Tumor (PEComa) of the Adrenal Gland: Report of a Rare Case Posing Diagnostic Challenge with the Role of Immunohistochemistry in the Diagnosis.Endocrine pathology · 2015Article
- Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review.Oncology letters · 2015Article
- Adrenal sarcomatoid carcinoma: a case report and review of the literature.The Ulster medical journal · 2014Review
- Adrenocortical carcinoma presenting as a rupture and extensive retroperitoneal haemorrhage.Journal of clinical and diagnostic research : JCDR · 2014Article
- Adrenal tumours are more predominant in females regardless of their histological subtype: a review.World journal of urology · 2013Review
- Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade.Langenbeck's archives of surgery · 2010Article
- Adrenocortical carcinosarcoma: a case report and review of the literature.Diagnostic pathology · 2010Review
- Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Primary adrenocortical sarcomatoid carcinoma: case report and review of literature.Virchows Archiv : an international journal of pathology · 2008Article
- Alpha-fetoprotein (AFP)-producing adrenocortical carcinoma--long survival with various therapeutic strategies including a lung resection: report of a case.Surgery today · 2008Article
- Combined liver and inferior vena cava resection for adrenocortical carcinoma.Surgery today · 2007Article
- Large idiopathic unilateral adrenal hematoma in a young woman.Journal of endocrinological investigation · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenocortical carcinoma (AC) is a rare tumor with poor prognosis. Twenty-two patients (14 F, 8 M; age 22 to 59 years; median, 43 years) with AC were evaluated prospectively in a single center: tumor stage was I-II in 12 cases and III-IV in 10. The overall survival in our cohort was 41.6 +/- 42 months; 16 subjects are still alive. Curative surgery was followed by longer survival than debulking or no surgery (p < 0.0001). The first relapse was highly predictive for further recurrences. Recurrent ACs were progressively more aggressive, and they occurred with variable but ever shorter intervals. At diagnosis, 14 patients (63.5%) presented with features of clear adrenocortical hyperactivity. Despite the absence of clinical signs of hormonal excess, all other patients presented some abnormalities of steroid secretion. The most common clinical finding was a recent diagnosis of moderate-to-severe hypertension (68%), poorly controlled by pharmacological treatment, often associated with multiple cardiovascular risk factors. High mitotic rate and undifferentiated polymorph cellular pattern were associated with worse prognosis. Response to treatments other than surgery (mitotane chemotherapy) was better in patients treated early after the first surgery. In conclusion, curative surgery was the most effective treatment. Monitoring arterial pressure, endocrine parameters, and metabolic parameters can be helpful for the early detection of AC recurrences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.