ReviewClinical pharmacokinetics1992
Clinical pharmacokinetics of antibiotics in patients with impaired renal function.
Review in Clinical pharmacokinetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Chemotherapy in patients with severely reduced glomerular filtration rate: challenges and a call for improvement.Journal of nephrology · 2025Article
- Physiologically Based Pharmacokinetic Model of Cefotaxime in Patients with Impaired Renal Function.Clinical pharmacokinetics · 2025Article
- Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease.Clinical kidney journal · 2024Review
- Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients.Clinical kidney journal · 2023Review
- Model-Informed Precision Dosing of Vancomycin in Adult Patients Undergoing Hemodialysis.Antimicrobial agents and chemotherapy · 2023Article
- Drug-Dosing Adjustment in Dogs and Cats with Chronic Kidney Disease.Animals : an open access journal from MDPI · 2022Review
- Pharmacokinetics in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Review
- Pharmacotherapeutic Management of Neuropathic Pain in End-Stage Renal Disease.Kidney diseases (Basel, Switzerland) · 2020Review
- Pharmacotherapeutic considerations for chronic pain in chronic kidney and end-stage renal disease.Journal of pain research · 2016Article
- Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock.Clinical pharmacokinetics · 2002Review
- Drug therapy in haemodialysis patients. Special considerations in the elderly.Drugs & aging · 1998Review
- Pharmacokinetics of drugs used in critically ill adults.Clinical pharmacokinetics · 1998Review
- Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration.Antimicrobial agents and chemotherapy · 1997Article
- Drug administration in patients with renal insufficiency. Minimising renal and extrarenal toxicity.Drug safety · 1997Review
- Effect of renal impairment on the pharmacokinetics of grepafloxacin.Clinical pharmacokinetics · 1997Article
- Pharmacokinetics of continuous renal replacement therapy.Intensive care medicine · 1995Review
- Effect of norfloxacin on theophylline disposition: a comparison with other fluoroquinolones.Pharmaceutical research · 1995Article
- Review
- Drug dosage in patients during continuous renal replacement therapy. Pharmacokinetic and therapeutic considerations.Clinical pharmacokinetics · 1993Review
- A Synopsis of Clinical Pharmacokinetic Alterations in Advanced CKD.Seminars in dialysisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many antibiotics are eliminated renally and dosage adjustments are commonly made in patients with renal insufficiency. This is a critical review of antibiotic pharmacokinetics in patients with various degrees of renal function. Detailed information regarding pharmacokinetic alterations with specific antibiotics or antibiotic classes has been compiled and tabulated. From pharmacokinetic evidence, recommendations for dosage adjustments of antibiotics are supplied. The criteria used for assigning rating levels to specific pharmacokinetic articles as well as the grading system for dosage adjustments are outlined. In addition, a basic review of pharmacokinetic alterations in renal failure and factors affecting the removal of drugs by haemodialysis is included.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.