ArticleChromosoma2005
The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID.
Article in Chromosoma, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Centromere structure and function: lessons from Drosophila.Genetics · 2023Article
- Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators.PLoS genetics · 2021Article
- Condensin I is required for faithful meiosis in Drosophila males.Chromosoma · 2020Article
- Article
- Multiple Functions of the Essential GeneG3 (Bethesda, Md.) · 2019Article
- Transcription of a B chromosome CAP-G pseudogene does not influence normal Condensin Complex genes in a grasshopper.Scientific reports · 2017Article
- Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles inG3 (Bethesda, Md.) · 2017Article
- Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei.PLoS genetics · 2016Article
- Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup.Scientific reports · 2015Article
- The condensin complexes play distinct roles to ensure normal chromosome morphogenesis during meiotic division in Arabidopsis.The Plant journal : for cell and molecular biology · 2014Article
- The cohesin subunit Rad21 is required for synaptonemal complex maintenance, but not sister chromatid cohesion, during Drosophila female meiosis.PLoS genetics · 2014Article
- Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I.PLoS genetics · 2013Article
- Condensin structures chromosomal DNA through topological links.Nature structural & molecular biology · 2011Article
- Centromeres: unique chromatin structures that drive chromosome segregation.Nature reviews. Molecular cell biology · 2011Review
- Xenopus HJURP and condensin II are required for CENP-A assembly.The Journal of cell biology · 2011Article
- One-hit wonders of genomic instability.Cell division · 2010Article
- Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.PloS one · 2009Article
- Intrakinetochore localization and essential functional domains of Drosophila Spc105.The EMBO journal · 2009Article
- Condensin regulates the stiffness of vertebrate centromeres.Molecular biology of the cell · 2009Article
- Article
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The centromere-specific histone H3 variant CENP-A plays a crucial role in kinetochore specification and assembly. We chose a genetic approach to identify interactors of the Drosophila CENP-A homolog CID. Overexpression of cid in the proliferating eye imaginal disk results in a rough eye phenotype, which is dependent on the ability of the overexpressed protein to localize to the kinetochore. A screen for modifiers of the rough eye phenotype identified mutations in the Drosophila condensin subunit gene Cap-G as interactors. Yeast two-hybrid experiments also reveal an interaction between CID and Cap-G. While chromosome condensation in Cap-G mutant embryos appears largely unaffected, massive defects in sister chromatid segregation occur during mitosis. Taken together, our results suggest a link between the chromatin condensation machinery and kinetochore structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.