ArticleOncogene2005
Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Computational meta-analysis of ribosomal RNA fragments: potential targets and interaction mechanisms.Nucleic acids research · 2021Pooled it
- Transcriptomic era of cancers in females: new epigenetic perspectives and therapeutic prospects.Frontiers in oncology · 2024Review
- Characterization of tRNA expression profiles in large offspring syndrome.BMC genomics · 2022Article
- Integrated genomic analysis reveals regulatory pathways and dynamic landscapes of the tRNA transcriptome.Scientific reports · 2021Article
- Small Non-Coding-RNA in Gynecological Malignancies.Cancers · 2021Review
- Riddle of the Sphinx: Emerging Role of Transfer RNAs in Human Cancer.Frontiers in pharmacology · 2021Review
- The dysregulation of tRNAs and tRNA derivatives in cancer.Journal of experimental & clinical cancer research : CR · 2018Review
- Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.Liver research (Beijing, China) · 2017Article
- YAMAT-seq: an efficient method for high-throughput sequencing of mature transfer RNAs.Nucleic acids research · 2017Article
- 5'-Terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5'-halves.RNA (New York, N.Y.) · 2017Article
- tRNAs as regulators of biological processes.Frontiers in genetics · 2014Review
- Dysregulation of the basal RNA polymerase transcription apparatus in cancer.Nature reviews. Cancer · 2013Review
- Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.The Journal of biological chemistry · 2013Article
- Applications of different weighting schemes to improve pathway-based analysis.Comparative and functional genomics · 2011Article
- Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes.Nature structural & molecular biology · 2010Article
- Regulation of TFIIIB during F9 cell differentiation.BMC molecular biology · 2010Article
- Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells.Nucleic acids research · 2010Article
- The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.BMC molecular biology · 2008Article
- Recruitment of RNA polymerase III in vivo.Nucleic acids research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA polymerase (pol) III transcription is a major determinant of biosynthetic capacity, providing essential products such as tRNA and 5S rRNA. It is controlled directly by the tumour suppressors RB and p53. High-risk types of human papillomavirus (HPV), such as HPV16, express the oncoproteins E6 and E7 that can inactivate p53 and RB, respectively. Accordingly, both E6 and E7 stimulate pol III transcription in cultured cells. HPV16-positive cervical biopsies express elevated levels of tRNA and 5S rRNA when compared to biopsies that test negative for HPV or are infected with the lower risk HPV11. Integration of viral DNA into the host cell genome stimulates expression of E6 and E7 and correlates with induction of tRNA and 5S rRNA. Expression of mRNA encoding the pol III-specific transcription factor Brf1 also correlates with the presence of integrated HPV16. Brf1 levels are limiting for tRNA and 5S rRNA synthesis in cervical cells. Furthermore, pol III-transcribed genes that do not use Brf1 are not induced in HPV16-positive biopsies. Three complementary mechanisms may therefore allow high-risk HPV to stimulate production of tRNA and 5S rRNA: E6-mediated removal of p53; E7-mediated neutralization of RB; and induction of Brf1. The resultant increase in biosynthetic capacity may contribute to deregulated cell growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.