ArticleOncogene2005
Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Friend or Foe: Regulation, Downstream Effectors of RRAD in Cancer.Biomolecules · 2023Review
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- Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.The Journal of biological chemistry · 2014Article
- Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer.Oncology reports · 2013Article
- Article
- Generation and characterization of Tmeff2 mutant mice.Biochemical and biophysical research communications · 2012Article
- Polycomb repressor complex-2 is a novel target for mesothelioma therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma.PloS one · 2011Article
- Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis.The American journal of pathology · 2010Article
- Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma.Cancer research · 2010Article
- hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma.Cancer research · 2010Article
- Histone deacetylase inhibitors in malignant pleural mesothelioma: preclinical rationale and clinical trials.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2010Review
- SV40-induced expression of calretinin protects mesothelial cells from asbestos cytotoxicity and may be a key factor contributing to mesothelioma pathogenesis.The American journal of pathology · 2009Article
- Identification of potential therapeutic targets in malignant mesothelioma using cell-cycle gene expression analysis.The American journal of pathology · 2009Article
- JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype.Neoplasia (New York, N.Y.) · 2009Article
- Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma.Carcinogenesis · 2008Article
- DNA methylation profile of 28 potential marker loci in malignant mesothelioma.Lung cancer (Amsterdam, Netherlands) · 2007Article
- Article
- Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.Oncogene · 2006Article
- DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers.British journal of cancer · 2005Article
Corrections and comments
- Retraction · 2004-12-13Duplication of/in Image · Manipulation of Images · Misconduct by Author ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Malignant mesothelioma (MM) is associated with asbestos exposure and the presence of SV40 viral sequences. Recently, we reported that SV40 infection of human mesothelial cells (HM) causes aberrant methylation of the tumor suppressor gene (TSG) RASSF1A. We investigated methylation of 12 genes by methylation-specific PCR in 63 MMs, six MM cell lines, and two foci of SV40-infected HM. Methylation percentages of the tested genes ranged from 3 to 65%. The frequencies of HPP1, RASSF1A, Cyclin D2, and RRAD methylation, and the value of the methylation index, were significantly higher in SV40 sequence-positive MMs than in SV40-negative MMs. Methylation of TMS1 and HIC-1 was associated with shortened survival. SV40-infected HM showed progressive aberrant methylation of seven genes (RASSF1A, HPP1, DcR1, TMS1, CRBP1, HIC-1, and RRAD) during serial passage. Our results demonstrate a relationship between SV40 and methylation of multiple genes in MM, indicating that the virus plays a role in the pathogenesis of MM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.