ArticleThe EMBO journal2005
RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 114 citations in OpenAlex.
- Article
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- Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.Hepatology (Baltimore, Md.) · 2022Article
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- A signalling cascade for Ral.Small GTPases · 2022Review
- Review
- Expression of Tight Junction Proteins Is Altered in Bladder Cancer.Analytical cellular pathology (Amsterdam) · 2020Article
- RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.Pharmacological reviews · 2018Review
- Ral signaling pathway in health and cancer.Cancer medicine · 2017Review
- Cold Shock Proteins Mediate GN with Mesangioproliferation.Journal of the American Society of Nephrology : JASN · 2016Article
- Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation.Scientific reports · 2016Article
- Tight junctions: from simple barriers to multifunctional molecular gates.Nature reviews. Molecular cell biology · 2016Review
- The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.Acta pharmacologica Sinica · 2015Review
- Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.Biochimica et biophysica acta · 2014Review
- MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival.The Journal of cell biology · 2014Article
- CCM1 and the second life of proteins in adhesion complexes.Cell adhesion & migration · 2014Review
- Ral GTPases in tumorigenesis: emerging from the shadows.Experimental cell research · 2013Review
- The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Ral proteins are members of the Ras superfamily of small GTPases and are involved in signalling pathways for actin cytoskeleton remodelling, cell cycle control, cellular transformation and vesicle transport. To identify novel RalA effector proteins, we used the reverse Ras recruitment system and found that RalA interacts with a Y-box transcription factor, ZO-1-associated nucleic acid-binding protein (ZONAB), in a GTP-dependent manner. The amount of the RalA-ZONAB complex increases as epithelial cells become more dense and increase cell contacts. The RalA-ZONAB interaction results in a relief of transcriptional repression of a ZONAB-regulated promoter. Additionally, expression of oncogenic Ras alleviates transcriptional repression by ZONAB in a RalA-dependent manner. The data presented here implicate the RalA/ZONAB interaction in the regulation of ZONAB function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.