ArticleGut2005
Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Genomic loss of MLH1/PMS2 loci defines a mismatch repair deficient subgroup in monomorphic epitheliotropic intestinal T-cell lymphoma.Blood cancer journal · 2026Article
- Low microsatellite instability revisited: a review.Virchows Archiv : an international journal of pathology · 2026Review
- Diagnostic Challenges and Clinical Implications of Microsatellite Instability/Mismatch Repair Deficiency in Solid Tumors.Cancer research and treatment · 2026Review
- InDEL instability in two different tumoral tissues and its forensic significance.Forensic science, medicine, and pathology · 2024Article
- Conditional Overall Survival After Diagnosis of Non-Metastatic Colon Cancer: Impact of Laterality, MSI, and KRAS Status.Annals of surgical oncology · 2024Article
- Effects of deficient mismatch repair on the prognosis of patients with stage II and stage III colon cancer during different postoperative periods.BMC cancer · 2022Article
- Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa.BMC cancer · 2022Article
- BAT26 Only Microsatellite Instability with High Tumor Mutation Burden-A Rare Entity Associated with PTEN Protein Loss and High PD-L1 Expression.International journal of molecular sciences · 2022Article
- Microsatellite Instability in Sporadic Colorectal Malignancy: A Pilot Study from Northern India.Asian Pacific journal of cancer prevention : APJCP · 2021Observational
- Low level of microsatellite instability correlates with short disease-free survival of gastric cancer patients undergoing neoadjuvant chemotherapy.Virchows Archiv : an international journal of pathology · 2021Article
- Serum Tumor Markers Combined With Clinicopathological Characteristics for Predicting MMR and KRAS Status in 2279 Chinese Colorectal Cancer Patients: A Retrospective Analysis.Frontiers in oncology · 2021Article
- MSI-L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients.Journal of cellular physiology · 2019Article
- Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer.World journal of gastrointestinal oncology · 2018Review
- Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer.Nucleic acids research · 2016Article
- Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients.Journal of oncology · 2016Article
- Low-Level Microsatellite Instability as a Potential Prognostic Factor in Sporadic Colorectal Cancer.Medicine · 2015Observational
- Circadian clock circuitry in colorectal cancer.World journal of gastroenterology · 2014Review
- Toward a molecular classification of colorectal cancer: the role of microsatellite instability status.Frontiers in oncology · 2013Review
- The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer.British journal of cancer · 2013Article
- High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancers (CRCs) may be categorised according to the degree of microsatellite instability (MSI) exhibited, as MSI-high (MSI-H), MSI-low (MSI-L), or microsatellite stable (MSS). MSI-H status confers a survival advantage to patients with sporadic CRC.
aimsTo determine if low levels of MSI are related to the clinicopathological features and prognosis of sporadic stage C CRC. PATIENTS: A total of 255 patients who underwent resection for sporadic stage C CRC were studied. No patient received chemotherapy. Minimum follow up was five years.
methodsDNA extracted from archival malignant and non-malignant tissue was amplified by polymerase chain reaction using a panel of 11 microsatellites. MSI-H was defined as instability at > or =40% of markers, MSS as no instability, and MSI-L as instability at >0% but <40% of markers. Patients with MSI-H CRC were excluded from analysis as they have previously been shown to have better survival.
resultsThirty three MSI-L and 176 MSS CRCs were identified. There was no difference in biological characteristics or overall survival of MSI-L compared with MSS CRC but MSI-L was associated with poorer cancer specific survival (hazard ratio 2.0 (95% confidence interval 1.1-3.6)).
conclusionsSporadic MSI-L and MSS CRCs have comparable clinicopathological features. Further studies are required to assess the impact of MSI-L on prognosis.
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