ArticleProceedings of the National Academy of Sciences of the United States of America2004
Vibration pattern of the organ of Corti up to 50 kHz: evidence for resonant electromechanical force.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 50 citations in OpenAlex.
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- The chloride-channel blocker 9-anthracenecarboxylic acid reduces the nonlinear capacitance of prestin-associated charge movement.The European journal of neuroscience · 2016Article
- Finite-element model of the active organ of Corti.Journal of the Royal Society, Interface · 2016Article
- Longitudinal spread of mechanical excitation through tectorial membrane traveling waves.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Electrokinetic properties of the mammalian tectorial membrane.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- How are inner hair cells stimulated? Evidence for multiple mechanical drives.Hearing research · 2012Article
- Article
- Metabolic imaging of the organ of corti--a window on cochlea bioenergetics.Brain research · 2009Article
- Medial olivocochlear efferent inhibition of basilar-membrane responses to clicks: evidence for two modes of cochlear mechanical excitation.The Journal of the Acoustical Society of America · 2008Article
- Sound-evoked radial strain in the hearing organ.Biophysical journal · 2007Article
- Imaging electrically evoked micromechanical motion within the organ of corti of the excised gerbil cochlea.Biophysical journal · 2007Article
- Distortion product otoacoustic emissions measured as vibration on the eardrum of human subjects.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Nanomechanics of the subtectorial space caused by electromechanics of cochlear outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Mechanical responses of the organ of corti to acoustic and electrical stimulation in vitro.Biophysical journal · 2005Article
- Nonlinear cochlear mechanics without direct vibration-amplification feedback.Physical review researchArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electromechanical force derived from the soma of the outer hair cell has long been postulated as the basis of the exquisite sensitivity of the cochlea. The problem with this postulate is that the electrical source and mechanical load for the electromechanical outer hair cell might be severely attenuated and phase-shifted by the electrical impedance of the cell and the mechanical impedance of the organ of Corti, respectively. Until now, it has not been possible to experimentally derive the high-frequency electrically induced force at the reticular lamina when the cells are embedded within the organ of Corti. In the study reported here, we succeeded in determining the frequency spectrum of the force up to 50 kHz. This was achieved by measuring both the electrically induced velocity and the mechanical impedance at different radial positions on the reticular lamina without tectorial membrane and with clamped basilar membrane. Velocity was measured with a laser interferometer and impedance, with a magnetically driven atomic force cantilever. The electromechanical force, normalized to the electric current density, exhibited a broad amplitude maximum at 7-20 kHz with a quality factor, Q(3dB), of 0.6 - 0.8. The displacement response was independent of frequency up to 10-20 kHz. The force response compensates for the viscoelastic impedance of the organ of Corti, extending the amplitude response of the organ to high frequencies. It is proposed that the electrical phase response of the cell is compensated with Zwislocki's original mechanism of a parallel resonance in the tectorial membrane-stereocilia complex.
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