ArticleJournal of medical genetics2004
Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease.
Article in Journal of medical genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease.BMC genetics · 2007Pooled it
- Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress.Brain, behavior, and immunity · 2020Article
- Impact of gene mutation in the development of Parkinson's disease.Genes & diseases · 2019Review
- The neuroprotective effects of hydro-alcoholic extract of olive (Olea europaea L.) leaf on rotenone-induced Parkinson's disease in rat.Metabolic brain disease · 2018Article
- Molecular Effects of L-dopa Therapy in Parkinson's Disease.Current genomics · 2014Article
- Parkinson disease loci in the mid-western Amish.Human genetics · 2013Article
- Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease.Human molecular genetics · 2012Article
- Using the BITOLA system to identify candidate genes for Parkinson's disease.Bosnian journal of basic medical sciences · 2011Article
- Epidemiology and etiology of Parkinson's disease: a review of the evidence.European journal of epidemiology · 2011Review
- Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.Human molecular genetics · 2010Article
- Spatial distribution of Parkinson's disease mortality in Spain, 1989-1998, as a guide for focused aetiological research or health-care intervention.BMC public health · 2009Article
- Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18.American journal of human genetics · 2009Article
- Genes associated with Parkinson syndrome.Journal of neurology · 2008Review
- The beat goes on--driven by a cardiac calcium clock?Heart rhythm · 2008Article
- Merging mouse transcriptome analyses with Parkinson's disease linkage studies.DNA research : an international journal for rapid publication of reports on genes and genomes · 2007Article
- The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations.Journal of medical genetics · 2006Article
- Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the Netherlands.Human genetics · 2006Article
- Population genetic approaches to neurological disease: Parkinson's disease as an example.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
objectiveTo undertake a full genome-wide screen for Parkinson's disease susceptibility loci.
methodsA genome-wide linkage study was undertaken in 227 affected sibling pairs from 199 pedigrees with Parkinson's disease. The pedigree sample consisted of 188 pedigrees from five European countries, and 11 from the USA. Individuals were genotyped for 391 microsatellite markers at approximately 10 cM intervals throughout the genome. Multipoint model-free affected sibling pair linkage analyses were carried out using the MLS (maximum LOD score) test.
resultsThere were six chromosomal regions with maximum MLS peaks of 1 or greater (pointwise p<0.018). Four of these chromosomal regions appear to be newly identified regions, and the highest MLS values were obtained on chromosomes 11q (MLS = 1.60, at 91 cM, D11S4175) and 7p (MLS = 1.51, at 5 cM, D7S531). The remaining two MLS peaks, on 2p11-q12 and 5q23, are consistent with excess sharing in regions reported by other studies. The highest MLS peak was observed on chromosome 2p11-q12 (MLS = 2.04, between markers D2S2216 and D2S160), within a relatively short distance (approximately 17 cM) from the PARK3 region. Although a stronger support of linkage to this region was observed in the late age of onset subgroup of families, these differences were not significant. The peak on 5q23 (MLS = 1.05, at 130 cM, D5S471) coincides with the region identified by three other genome scans. All peak locations fell within a 10 cM distance.
conclusionsThese stratified linkage analyses suggest linkage heterogeneity within the sample across the 2p11-q12 and 5q23 regions, with these two regions contributing independently to Parkinson's disease susceptibility.
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