ArticleBritish journal of pharmacology1992
Direct action of BRL 38227 and glibenclamide on intracellular calcium stores in cultured airway smooth muscle of rabbit.
Article in British journal of pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- Monophasic action potentials and CaNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2003Article
- Nuclear KATP channels trigger nuclear Ca(2+) transients that modulate nuclear function.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Mechanism of hypoxic K loss in rabbit ventricle.The Journal of clinical investigation · 1997Article
- Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Ionic currents and inhibitory effects of glibenclamide in seminal vesicle smooth muscle cells.British journal of pharmacology · 1995Article
- Pharmacology of the potassium channel openers.Cardiovascular drugs and therapy · 1995Review
- Comparison of the cromakalim antagonism and bradycardic actions of a series of novel alinidine analogues in the rat.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Levcromakalim-induced modulation of membrane potassium currents, intracellular calcium and mechanical activity in rat mesenteric artery.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Effects of rubidium on responses to potassium channel openers in rat isolated aorta.British journal of pharmacology · 1993Article
- Characteristics of the contractile response of rabbit aorta produced by cromakalim in calcium-free solution.British journal of pharmacology · 1992Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of BRL 38227 and glibenclamide on intracellular calcium stores were investigated in permeabilized cultured airway smooth muscle cells of the rabbit using 45Ca effluxes. BRL 38227 (10 microM) reduced loading of the inositol 1,4,5-trisphosphate (InsP3)-sensitive intracellular store by 26.5% +/- 1.0; this effect was antagonized by 1 microM glibenclamide. BRL 38227 itself did not release calcium and had no effect on guanosine 5'-0-(3-thiotriphosphate)-induced calcium release. Glibenclamide (greater than or equal to 5 microM) also reduced calcium loading of the intracellular store, and enhanced calcium release. These results suggest that BRL 38227 has a direct effect on intracellular calcium handling.
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