ArticleGenome research2005
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA-DNA triplexes and HP1 binding.Nature cell biology · 2022Article
- Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens.Scientific reports · 2021Article
- Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.The Journal of cell biology · 2014Article
- Targeted gene suppression by inducing de novo DNA methylation in the gene promoter.Epigenetics & chromatin · 2014Article
- No Evidence for a Parent-of-Origin Specific Differentially Methylated Region Linked to RASGRF1.Frontiers in genetics · 2012Article
- The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility.ILAR journal · 2012Review
- Unique patterns of evolutionary conservation of imprinted genes.Clinical epigenetics · 2011Article
- BACs as tools for the study of genomic imprinting.Journal of biomedicine & biotechnology · 2011Review
- Imprinted genes show unique patterns of sequence conservation.BMC genomics · 2010Article
- ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs.RNA (New York, N.Y.) · 2010Article
- Divergence of imprinted genes during mammalian evolution.BMC evolutionary biology · 2010Article
- The imprinted Phlda2 gene regulates extraembryonic energy stores.Molecular and cellular biology · 2010Article
- The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.Human molecular genetics · 2009Article
- Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region.Molecular and cellular biology · 2008Article
- Evolution of the CDKN1C-KCNQ1 imprinted domain.BMC evolutionary biology · 2008Article
- Recent assembly of an imprinted domain from non-imprinted components.PLoS genetics · 2006Article
- Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes.Genes & development · 2006Article
- Is imprinting in printing or in press?Journal of molecular medicine (Berlin, Germany) · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes around imprinting control centers (ICs) is regarded as a hallmark for the coordinated imprinted regulation. Hence imprinted clusters might be structurally distinct between mammals and nonimprinted vertebrates. To address this question we compared the organization of the Beckwith Wiedemann syndrome (BWS) gene cluster in mammals, chicken, Fugu (pufferfish), and zebrafish. Our analysis shows that gene synteny is apparently well conserved between mammals and birds, and is detectable but less pronounced in fish. Hence, clustering apparently evolved during vertebrate radiation and involved two major duplication events that took place before the separation of the fish and mammalian lineages. A cross-species analysis of imprinting center regions showed that some structural features can already be recognized in nonimprinted amniotes in one of the imprinting centers (IC2). In contrast, the imprinting center IC1 is absent in chicken. This suggests a progressive and stepwise evolution of imprinting control elements. In line with that, imprinting centers in mammals apparently exhibit a high degree of structural and sequence variation despite conserved epigenetic marking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.