ArticleGenome research2005
Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Differences in gene expression between first and third trimester human placenta: a microarray study.PloS one · 2012Trial
- Building Haplotype-Resolved 3D Genome Maps of Chicken Skeletal Muscle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- annotate_my_genomes: an easy-to-use pipeline to improve genome annotation and uncover neglected genes by hybrid RNA sequencing.GigaScience · 2022Article
- Transcriptome analysis revealed misregulated gene expression in blastoderms of interspecific chicken and Japanese quail F1 hybrids.PloS one · 2020Article
- Embryonic development and inviability phenotype of chicken-Japanese quail F1 hybrids.Scientific reports · 2016Article
- Effect of in ovo folic acid injection on hepatic IGF2 expression and embryo growth of broilers.Journal of animal science and biotechnology · 2016Article
- Transcriptome-wide investigation of genomic imprinting in chicken.Nucleic acids research · 2014Article
- Epigenetics and phenotypic variability: some interesting insights from birds.Genetics, selection, evolution : GSE · 2013Review
- Gene expression and DNA methylation status of chicken primordial germ cells.Molecular biotechnology · 2013Article
- Genome-wide mapping of DNA methylation in chicken.PloS one · 2011Article
- BACs as tools for the study of genomic imprinting.Journal of biomedicine & biotechnology · 2011Review
- The imprinted Phlda2 gene regulates extraembryonic energy stores.Molecular and cellular biology · 2010Article
- The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.Human molecular genetics · 2009Article
- Article
- Recent assembly of an imprinted domain from non-imprinted components.PLoS genetics · 2006Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds. Igf2 lies in a large imprinted cluster in eutherians, and its imprinting is regulated by long-range mechanisms. As a step to understand how the imprinted cluster evolved, we have determined a 490-kb chicken sequence containing the orthologs of mammalian Ascl2/Mash2, Ins2 and Igf2. We found that most of the genes in this region are conserved between chickens and mammals, maintaining the same transcriptional polarities and exon-intron structures. However, H19, an imprinted noncoding transcript, was absent from the chicken sequence. Chicken ASCL2/CASH4 and INS, the orthologs of the imprinted mammalian genes, showed biallelic expression, further supporting the notion that imprinting evolved after the divergence of mammals and birds. The H19 imprinting center and many of the local regulatory elements identified in mammals were not found in chickens. Also, a large segment of tandem repeats and retroelements identified between the two imprinted subdomains in mice was not found in chickens. Our findings show that the imprinted genes were clustered before the emergence of imprinting and that the elements associated with imprinting probably evolved after the divergence of mammals and birds.
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