ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 115 citations in OpenAlex.
- Phylogenomic analysis of vocal fold length evolution reveals links between vocal and auditory systems in terrestrial mammals.Molecular biology and evolution · 2026Article
- Efferent Inhibition of Hair Cells: Past, Present and Future.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Dysferlin Protein-Protein Interaction Pathways in the Organ of Corti and Spiral Ganglion Intersect with Alzheimer's Protein Pathways.International journal of molecular sciences · 2025Article
- Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea.iScience · 2024Article
- Regulation of cochlear hair cell function by intracellular calcium stores.Frontiers in cellular neuroscience · 2024Article
- Genetic tools for studying cochlear inhibition.Frontiers in cellular neuroscience · 2024Review
- Intestinal enteroendocrine cells rely on ryanodine and IPThe Journal of physiology · 2023Article
- Synaptic Contributions to Cochlear Outer Hair Cell CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice.Scientific reports · 2021Article
- Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Cholinergic Lateral Line Efferent Synapse: Structural, Functional and Molecular Similarities With Those of the Cochlea.Frontiers in cellular neuroscience · 2021Review
- SK Current, Expressed During the Development and Regeneration of Chick Hair Cells, Contributes to the Patterning of Spontaneous Action Potentials.Frontiers in cellular neuroscience · 2021Article
- Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells.The Journal of physiology · 2020Article
- Efferent synaptic transmission at the vestibular type II hair cell synapse.Journal of neurophysiology · 2020Article
- A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.Journal of neurophysiology · 2020Review
- Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea.The Journal of physiology · 2020Article
- Article
- Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells.The EMBO journal · 2019Article
- Efferent Inhibition of the Cochlea.Cold Spring Harbor perspectives in medicine · 2019Review
- Characterization of transgenic mouse lines for labeling type I and type II afferent neurons in the cochlea.Scientific reports · 2019Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.