ArticleEukaryotic cell2004
Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Comprehensive analysis of the expression and prognostic value of ARMCs in pancreatic adenocarcinoma.BMC cancer · 2025Article
- ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases.Frontiers in molecular biosciences · 2021Review
- Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1.Molecular and cellular biology · 2017Article
- Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.The EMBO journal · 2017Article
- A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology.PloS one · 2011Article
- Transcriptomic changes arising during light-induced sporulation in Physarum polycephalum.BMC genomics · 2010Article
- An increase in mitochondrial DNA promotes nuclear DNA replication in yeast.PLoS genetics · 2008Article
- The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.Biochemical and biophysical research communications · 2007Article
- A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition.Current genetics · 2007Article
- Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae.EMBO reports · 2006Article
- Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.Current genetics · 2006Article
- Bem1p, a scaffold signaling protein, mediates cyclin-dependent control of vacuolar homeostasis in Saccharomyces cerevisiae.Genes & development · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
How cells determine when to initiate DNA replication is poorly understood. Here we report that in Saccharomyces cerevisiae overexpression of the dosage-dependent cell cycle regulator genes DCR2 (YLR361C) and GID8 (DCR1/YMR135C) accelerates initiation of DNA replication. Cells lacking both GID8 and DCR2 delay initiation of DNA replication. Genetic analysis suggests that Gid8p functions upstream of Dcr2p to promote cell cycle progression. DCR2 is predicted to encode a gene product with phosphoesterase activity. Consistent with these predictions, a DCR2 allele carrying a His338 point mutation, which in known protein phosphatases prevents catalysis but allows substrate binding, antagonized the function of the wild-type DCR2 allele. Finally, we report genetic interactions involving GID8, DCR2, and CLN3 (which encodes a G(1) cyclin) or SWI4 (which encodes a transcription factor of the G(1)/S transcription program). Our findings identify two gene products with a probable regulatory role in the timing of initiation of cell division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.