ArticleMicrobiology and molecular biology reviews : MMBR2004
Streamlined regulation and gene loss as adaptive mechanisms in Prochlorococcus for optimized nitrogen utilization in oligotrophic environments.
Article in Microbiology and molecular biology reviews : MMBR, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 122 citations in OpenAlex.
- Abiotic sources of fixed nitrogen sustained early ecosystems for several hundred million years after the origin of life.Science advances · 2026Article
- Wildfire-Driven Changes in Terrestrial Subsidies Shift Freshwater Microbial and Zooplankton Communities to New Compositional States.Molecular ecology · 2025Article
- Mesoscale eddies shape Prochlorococcus community structure and dynamics in the oligotrophic open ocean.The ISME journal · 2025Article
- Coexistence of Dominant Marine Phytoplankton Sustained by Nutrient Specialization.Microbiology spectrum · 2023Article
- A Reduction of Transcriptional Regulation in Aquatic Oligotrophic Microorganisms Enhances Fitness in Nutrient-Poor Environments.Microbiology and molecular biology reviews : MMBR · 2023Review
- MarineMicrobiology spectrum · 2022Article
- An Extremely Streamlined Macronuclear Genome in the Free-Living Protozoan Fabrea salina.Molecular biology and evolution · 2022Article
- Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria.Biochemical Society transactions · 2021Review
- Metagenomic Analysis Reveals Microbial Community Structure and Metabolic Potential for Nitrogen Acquisition in the Oligotrophic Surface Water of the Indian Ocean.Frontiers in microbiology · 2021Article
- Unlocking the Genomic Taxonomy of the Prochlorococcus Collective.Microbial ecology · 2020Article
- Multiple global change stressor effects on phytoplankton nutrient acquisition in a future ocean.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Grand Challenges in Microbe-Driven Marine Carbon Cycling Research.Frontiers in microbiology · 2020Article
- Article
- Article
- The Distinctive Regulation of Cyanobacterial Glutamine Synthetase.Life (Basel, Switzerland) · 2018Review
- Bacterial Diversity and Nitrogen Utilization Strategies in the Upper Layer of the Northwestern Pacific Ocean.Frontiers in microbiology · 2018Article
- Watershed-Induced Limnological and Microbial Status in Two Oligotrophic Andean Lakes Exposed to the Same Climatic Scenario.Frontiers in microbiology · 2018Article
- Fundamental differences in diversity and genomic population structure between Atlantic and Pacific Prochlorococcus.The ISME journal · 2017Article
- Where less may be more: how the rare biosphere pulls ecosystems strings.The ISME journal · 2017Article
- Differential NtcA Responsiveness to 2-Oxoglutarate Underlies the Diversity of C/N Balance Regulation inFrontiers in microbiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prochlorococcus is one of the dominant cyanobacteria and a key primary producer in oligotrophic intertropical oceans. Here we present an overview of the pathways of nitrogen assimilation in Prochlorococcus, which have been significantly modified in these microorganisms for adaptation to the natural limitations of their habitats, leading to the appearance of different ecotypes lacking key enzymes, such as nitrate reductase, nitrite reductase, or urease, and to the simplification of the metabolic regulation systems. The only nitrogen source utilizable by all studied isolates is ammonia, which is incorporated into glutamate by glutamine synthetase. However, this enzyme shows unusual regulatory features, although its structural and kinetic features are unchanged. Similarly, urease activities remain fairly constant under different conditions. The signal transduction protein P(II) is apparently not phosphorylated in Prochlorococcus, despite its conserved amino acid sequence. The genes amt1 and ntcA (coding for an ammonium transporter and a global nitrogen regulator, respectively) show noncorrelated expression in Prochlorococcus under nitrogen stress; furthermore, high rates of organic nitrogen uptake have been observed. All of these unusual features could provide a physiological basis for the predominance of Prochlorococcus over Synechococcus in oligotrophic oceans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.