ArticlePlant molecular biology1992
The beta-tubulin gene family of pea: primary structures, genomic organization and intron-dependent evolution of genes.
Article in Plant molecular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 61 citations in OpenAlex.
- Characterization and putative post-translational regulation of α- and β-tubulin gene families in Salix arbutifolia.Scientific reports · 2016Article
- Advances in plant gene-targeted and functional markers: a review.Plant methods · 2013Article
- Evolution of GHF5 endoglucanase gene structure in plant-parasitic nematodes: no evidence for an early domain shuffling event.BMC evolutionary biology · 2008Article
- Molecular characterization of the cotton GhTUB1 gene that is preferentially expressed in fiber.Plant physiology · 2002Article
- Evolution of intron/exon structure of DEAD helicase family genes in Arabidopsis, Caenorhabditis, and Drosophila.Genome research · 2001Article
- Intron "sliding" and the diversity of intron positions.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Article
- Developmental expression and regulation by light of two closely related beta-tubulin genes in Lupinus albus.Plant molecular biology · 1996Article
- Molecular evolution of nitrate reductase genes.Journal of molecular evolution · 1996Article
- Ferritin gene organization: differences between plants and animals suggest possible kingdom-specific selective constraints.Journal of molecular evolution · 1996Article
- Organization of the histone H3 genes in soybean, barley and wheat.Molecular & general genetics : MGG · 1996Article
- Characterization of an endo-beta-1,4-glucanase gene induced by auxin in elongating pea epicotyls.Plant physiology · 1996Article
- The marine red alga Chondrus crispus has a highly divergent beta-tubulin gene with a characteristic 5' intron: functional and evolutionary implications.Plant molecular biology · 1995Article
- The Pisum sativum TubA1 gene, a member of a small family of alpha-tubulin sequences.Plant molecular biology · 1995Article
- Isolation and characterization of two beta-tubulin cDNA clones from rice.Plant molecular biology · 1994Article
- Characterisation of the cDNA clones of two beta-tubulin genes and their expression in the potato plant (Solanum tuberosum L.).Plant molecular biology · 1994Article
- A highly conserved alpha-tubulin sequence from Prunus amygdalus.Plant molecular biology · 1993Article
- Molecular cloning and sequencing analysis of a beta-tubulin gene from Lupinus albus.Plant molecular biology · 1993Article
- Are tubulin isotypes functionally significant.Molecular biology of the cell · 1993Review
- The intron of Arabidopsis thaliana polyubiquitin genes is conserved in location and is a quantitative determinant of chimeric gene expression.Plant molecular biology · 1993Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One gene and two cDNAs encoding three different beta-tubulins (TUB1, TUB2, TUB3) of pea have been cloned and sequenced. The derived amino acid sequences show between 92% and 96% identity relative to one another and to most other beta-tubulins of higher plants and green algae. Two notable extremes are the high similarity of 98% between pea TUB3 and maize beta-tubulin 2 and the relatively low similarity (90%) of the hypocotyl-specific beta-tubulin 1 of soybean to the pea sequences. These similarities do not reflect the molecular phylogeny but rather differences in evolutionary rate of beta-tubulins which are differentially regulated during plant development. Genomic Southern blots reveal a beta-tubulin gene family in pea with at least four separate members including two TUB1 genes, one TUB2 gene and one TUB3 gene. This contradicts an earlier report by Raha et al. (Plant Mol Biol 9: 565-571, 1987) suggesting a tandem repeat organization of tubulin genes in pea. The pea TUB1 gene has two introns in identical positions compared to the beta-tubulin genes from Arabidopsis and soybean. In an attempt to reconstruct the universal ancestor of all present-day tubulin genes the intron positions in 38 different alpha- and beta-tubulin genes from plants, animals, fungi and protozoa were compared. This comparison shows that the primordial gene probably had many introns (more than 20) separating 'protoexons' of 15 to 20 codons in agreement with the 'exon theory of genes'. It also supports the view that, during the course of evolution, introns have shifted and were deleted preferentially in the 3' part of the genes. Similar observations have been made previously for other genes. They can be interpreted in terms of a homologous recombination of genes with their modified (incorrectly spliced) and reverse-transcribed pre-mRNAs.
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