ArticleCurrent biology : CB2004
Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis.
Article in Current biology : CB, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 76 citations in OpenAlex.
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- Cell cycle control during early embryogenesis.Development (Cambridge, England) · 2021Article
- Temporal Gradients Controlling Embryonic Cell Cycle.Biology · 2021Review
- Divergent Gene Expression Following Duplication of Meiotic Genes in the Stick Insect Clitarchus hookeri.Genome biology and evolution · 2021Article
- Regulators of TNFα mediated insulin resistance elucidated by quantitative proteomics.Scientific reports · 2020Article
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- Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos.PLoS genetics · 2020Article
- Histone concentration regulates the cell cycle and transcription in early development.Development (Cambridge, England) · 2019Article
- Review
- Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.Developmental cell · 2016Article
- Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.Trends in genetics : TIG · 2016Review
- Measuring time during early embryonic development.Seminars in cell & developmental biology · 2016Review
- The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.Molecular biology of the cell · 2015Article
- Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.ACS medicinal chemistry letters · 2015Article
- Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos.Developmental cell · 2014Article
- Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins.Biology open · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Cyclin-dependent kinases (Cdks) are the central regulators of the cell division cycle. Inhibitors of Cdks ensure proper coordination of cell cycle events and help regulate cell proliferation in the context of tissues and organs. Wee1 homologs phosphorylate a conserved tyrosine to inhibit the mitotic cyclin-dependent kinase Cdk1. Loss of Wee1 function in fission or budding yeast causes premature entry into mitosis. The importance of metazoan Wee1 homologs for timing mitosis, however, has been demonstrated only in Xenopus egg extracts and via ectopic Cdk1 activation . Here, we report that Drosophila Wee1 (dWee1) regulates Cdk1 via phosphorylation of tyrosine 15 and times mitotic entry during the cortical nuclear cycles of syncytial blastoderm embryos, which lack gap phases. Loss of maternal dwee1 leads to premature entry into mitosis, mitotic spindle defects, chromosome condensation problems, and a Chk2-dependent block of subsequent development, and then embryonic lethality. These findings modify previous models about cell cycle regulation in syncytial embryos and demonstrate that Wee1 kinases can regulate mitotic entry in vivo during metazoan development even in cycles that lack a G2 phase.
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